Following a shift in violent animal behavior, the team attempt to rescue Jamie and secure the leopard that could hold the key to curing the animal crisis.

In an effort to unravel a dark conspiracy within the Noah Objective, the team travels to Vancouver, where it must infiltrate a black-tie event in order to get close to General Davies and stave off an impending animal threat. Also, Jamie and Logan's journey is interrupted when Logan's past comes back to haunt them.

The team travels to Portugal where they square off against a dangerous venom dealer in order to get one step closer to the cure. Also, Jackson's increasingly erratic behavior jeopardizes the entire team.

With Jackson missing, Mitch and Abraham race to find him before General Davies and the International Animal Defense Group can locate him and prevent the team from making a cure. Also, Jamie, Dariela and Allison make a last-ditch effort to convince the Russian government to drop out of the Noah Objective.

Mitch seeks to rescue Clementine from her captors, and a glimpse into Jackson’s sister Abigail’s past reveals the origins of the hybrids.