In celebration of Empire's 20th Anniversary, Lucious makes his first public appearance since the explosion in Las Vegas, but still has no memory of his family, Empire or his life before the accident. A devastated Cookie struggles to rebuild her relationship with him, while keeping a close eye on his nurse, Claudia. Meanwhile, Andre is faced with an investigation by the LAPD surrounding the night of the explosion, Diana DuBois continues her war against the Lyons.

With Leah still insisting that he is a monster, Lucious sneaks away in hopes of finding out what type of person he was before the explosion. Cookie panics that Lucious has gone missing on Claudia's watch, until she realizes he found his way to Uncle Eddie, a music icon who has since become family to the Lyons. Meanwhile, with Anika still behind bars, Hakeem and Tiana grow more comfortable as a family, and Becky makes a rash decision regarding Jamal's new song.

When Cookie is denied a line of credit, she flashes back to her years in prison and compares her past struggles to her life now. Lucious continues to struggle with demons of his own and begs his family to tell him about the ways he's wronged them, but they are reluctant to tell him the truth. Meanwhile, the NYPD is still on Andre's case about the events that transpired in Vegas and one officer in particular catches his eye.

The race is on when Cookie announces that the number one album for Empire's 20-For-20 will be a competition between all of the label's top artists, giving Jamal a bold idea for his newest song. On the heels of Bella's first birthday, the family plans a special "Prince and Princesses"-themed birthday party, including a special Prince tribute, but the special day brings back haunting memories for one of the Lyons. Meanwhile, Lucious is at a crossroads, as he tries to put to rest the anger from his past life.

When the secret about Lucious' memory is exposed, Cookie attempts to convince the board that he is fine by inviting the press to watch him produce the first 20 for 20 album. Eddie Barker jumps in to help Lucious get back in his groove and make music in the studio. Just as Andre's feelings for Detective Pamela Rose intensify, she reveals information that's been uncovered regarding the explosion. Meanwhile, Hakeem worries about his secret involvement with the DuBois family and Claudia helps Lucious with a breakthrough.

The Lyon family stands together as Anika and Hakeem begin a custody battle for Bella. Although they're confident in Hakeem's ability as a father, no one is prepared for the revelations her team brings to the trial. Meanwhile, Claudia grows more possessive over Lucious, who has unlocked a new way to understand music through his paintings. Also, Jamal introduces Warren to Lucious, Andre begins seeing a new therapist, and one of Becky's old flames returns.

Calvin und Portia streiken und Cookie muss schnell eine passende Lösung finden. Lucious versucht sich zu beweisen, indem er einen Deal in Hakeems Namen organisiert. Jamal und Andre teilen ihren Partnern ihre Gefühle mit.

Cookie and Lucious take matters into their own hands as they watch Diana DuBois' master scheme unfold. Meanwhile, Andre begins to spiral out of control, wondering what she could have in store for him. Also, Jamal's sobriety is put to the test and Shine gives Hakeem advice on how to maintain a balance between his work and personal life.

Cookie and Lucious devise an elaborate plan to take down Diana Dubois and her family once and for all. Andre recovers from his mental breakdown in the hospital, Shine tries desperately to protect his secret and Eddie Barker is concluding his tenure at Empire. Amidst the chaos, someone's life hangs in the balance.

Nurse Claudia takes her job to a new level, when she kidnaps Lucious. To find him, Cookie must race against time and use the skills she learned in prison to rescue him. Meanwhile, Andre, Jamal and Hakeem pick up the pieces from their battle with the Dubois family.

On the brink of a lucrative tech deal, Eddie realizes that he must work on rebranding Empire. Cookie springs into action when a girl group from the past re-unites and threatens to expose secrets about Empire and Lucious. Meanwhile, Hakeem makes a major move with Tiana, Andre continues to struggle with his guilt and Becky is faced with a difficult situation.

Eine falsche gesundheitliche Diagnose innerhalb der Familie Lyon sendet eine Schockwelle durch das Empire. Andre und Jamal wollen ihre vergangenen Fehler wiedergutmachen und Jamal macht im Fernsehen eine schockierende Ankündigung.

Lucious bittet Cookie, die Dinge leichter anzugehen, doch als es um einen alten Freund geht, nimmt sie erneut die Dinge in ihre eigenen Hände. Tianas neue Single geht durch die Decke und Jamal hat Probleme damit, sich neu zu erfinden.

Lucious und Thirsty wollen Eddie bei der Übernahme des Empire einen Strich durch die Rechnung machen und konfrontieren ihn mit juristischen Dokumenten. Andre greät ins Straucheln und Hakeem entwickelt eine Strategie für den Release seines Songs.

Eddie kämpft um seinen Platz im Empire und es gelingt ihm, sich den Vorstand auf seine Seite zu holen. Lucious und Shine suchen derweil nach einer Möglichkeit, ihn fernzuhalten und Cookie bemüht sich, ein wichtiges Versprechen einzulösen.

When Cookie finally visits her mother, the two must confront their complicated past. Meanwhile, Lucious and Eddie continue their fight over Empire and Eddie makes a power play at the grand opening of Empire's 20 for 20 showcase. Then, Jamal and his band anonymously release their latest single and Hakeem tests out a career in film.

Cookie and Lucious fight to keep Empire in the family, as they prepare a livestream concert to crowdfund the amount needed to trump Eddie's plans. Meanwhile, the success of Jamal's new anonymous group climbs, Hakeem brings Haven to the showcase to make Tiana jealous, and Andre is put to the test and must decide between the family or his career.

As the Empire ownership bid presentation nears, Lucious must make a difficult decision to save the future of the company and his family, while Eddie shows no signs of backing down. However, Cookie reveals a potential upper hand in the power play for Empire, after doing a little digging into her past. Meanwhile, Andre makes a power play of his own, Hakeem's high spirits comes to a quick end due to a threat, Jamal and Tory struggle to cope with the success of their new music group, tension boils as the Lyons face Empire's most existential threat yet and someone's past mistakes leads to a deadly consequence. Season Finale.