When a slot opens up in the graduate program that Jane has been waiting for, she is faced with her first big motherhood dilemma -- leaving Mateo sooner than expected. Rafael is still reeling from Petra's news as he tries to help plan Mateo's baptism with Jane. Xo helps Rogelio confront his past even though it makes Xo uncomfortable. Meanwhile, Michael takes some advice from Rogelio about how to handle Jane, but it is easier said than done for him.

Jane and Rafael begin estate planning for Mateo, but when Jane realizes that Mateo will inherit millions, she worries he will become spoiled. Jane is also finally starting graduate school, but her professor is not sympathetic to her situation. Rogelio's famous show is ending, so he decides to create his own show, with Xo's encouragement. Petra is shocked to learn what she is having and turns to Jane for advice and help in getting her mother out of prison. Meanwhile, after Michael's issues at work, he has decided to go rogue and is even more determined to catch Sin Rostro.

Jane's latest parenting obstacle is sleep training Mateo, a struggle that has the Villanueva woman divided on what is the best method. At the same time, she is beginning her new job as a TA and is faced with a class full of basketball players looking for an easy A. Petra confesses all to Rafael and is determined to put her mother away for good. Rogelio's mother Liliana comes for a visit and reveals a 40 year old family secret. Meanwhile, Michael discovers the truth about Luisa's mother and new information about Rafael's mother.

Jane is considering whether or not to take her relationship with Jonathan to the next level and turns to Xo for advice. Xo and Rogelio have their own relationship issues to work out. Meanwhile, as a favor to Rafael, Jane agrees to help Petra by throwing her a baby shower. Luisa is in a terrible car accident, but all is not as it seems. Michael comes to a realization he must share with Jane.

Rafael and Petra are new parents but Petra is already back to work and appears to be not interested in motherhood. Xo has invited Alba's old flame Pablo to visit. This does not sit well with Alba as she believes Pablo is cursed and will bring bad luck. Jane is growing concerned that she can't get in touch with her father, Rogelio, who is being held captive by Lola.