A l’hôpital Ocean Park de Los Angeles, des jeunes patients sont confrontés aux questions de la vie et de la mort. Charlie, un petit garçon de 12 ans, est plongé dans le coma. Cependant, même s‘il ne voit rien, il entend tout. Sa partenaire de chambre, Kara, est une petite peste de cheerleader âgée de 16 ans, atteinte d'une insuffisance cardiaque. Jordi, lui, a franchi illégalement la frontière mexicaine en Californie, afin d’obtenir un traitement dans cet établissement de renom, où il se découvre de nouveaux amis. Léo, 16 ans, est indépendant et charismatique, mais après avoir vécu un an à l’hôpital, il commence à perdre espoir. Lorsqu’il est obligé de partager sa chambre avec Jordi, il ne l’accepte pas facilement. Cependant, il finit par se rendre compte qu’il y a plus de similitudes entre eux qu’il ne le pensait. Son meilleur ami, Dash, est un adolescent de 16 ans qui souffre d’une fibrose kystique. Il décide ainsi de vivre chaque jour comme si c’était le dernier. Au sein du service, il y a également Emma, 15 ans, l'ex-petite amie de Léo, qui se bat contre ses troubles alimentaires. Le Dr McAndrew, l’infirmière Jackson et la nouvelle infirmière Dobler sont là pour les encadrer, les soigner, mais aussi pour les aider...

Leo goes into a tailspin when Jordi's surgery doesn't proceed as expected; family members turn to their connections in hope of procuring a donor heart for Kara.

Friendships start to form when Jordi starts his treatment; Kara goes back to school; Emma attends her first dance; and Leo finds himself in an awkward position.

When the truth about Charlie's accident comes out, Nurse Jackson crosses a line to keep a promise to him; Jordi gets the freedom he wants.

After Leo abandons Emma, Jordi makes his move. A new patient puts Kara off balance and nurse Jackson fights to keep Charlie at Ocean Park.

Kara, Hunter, Jordi and Dash band together in support of Nurse Jackson, whose actions have caught up with her. Meanwhile, Emma meets Leo's friends from home, and one of the kids' circumstances changes dramatically.

Dr. Naday comes to Ocean Park Hospital, although his approach to treatment has Nurse Jackson questioning that decision. Meanwhile, Emma, Dash and Jordi search of the perfect gift, and Kara learns the truth about Hunter.

Romance is in bloom at Ocean Park Hospital, as things heat up between Kara and Hunter. Also, Leo and Emma get romantic, as Emma gets unexpected news. Meanwhile, Dr. McAndrew tries to win Dr. Grace back.

Emma goes home and Jordi is on the edge of doing something illegal.

Someone's unexpected return reveals a betrayal, while another "red bander" fights for freedom. Then, a battle is lost.

The group copes with the loss of one of their own, which results in new hope for one of them. Love is in the air as Nurse Jackson and Dr. Naday take things to a new level, however Dash's love interest could cost him his life. Shocking news leads to new hope and Emma and Kara start facing their family issues.

The group copes with the loss of one of their own, which results in new hope for one of them. Love is in the air as Nurse Jackson and Dr. Naday take things to a new level, however Dash's love interest could cost him his life. Shocking news leads to new hope and Emma and Kara start facing their family issues