Sebastian is placed on administrative leave after his response in a foot chase to apprehend a high-value fugitive is questioned by the FBI. Meanwhile, Pride and the team continue to track the target and try to clear Sebastian’s name.

FBI Special Agent Raymond Isler asks Pride for help with an off-the-books opioids theft investigation he is personally invested in. Also, Percy is sent undercover as a getaway driver with Isler as the muscle for a job tied to the case.

When journalist Oliver Crane posts a scathing article documenting Pride’s “reckless use of justice,” the team is concerned about the fallout from the piece and the confidential information included in the story. Also, Rita Devereaux warns Pride that someone in D.C. has coordinated this attack on him, and the article is just the beginning.

After a petty officer is found murdered under a shrimping boat, the NCIS investigation uncovers a conspiracy in the tight-knit local fishing community. Also, Lasalle awaits the final results of the tax fraud investigation into his family’s company.

While undercover, Gregorio joins a social club for military wives after one of the members is contacted by an ex-boyfriend on the FBI Most Wanted List.

Pride and Lasalle travel to war-torn South Ossetia in Russia to locate FBI Special Agent Raymond Isler, who was kidnapped during a failed mission to apprehend the leader of Apollyon, the underground spy network responsible for murdering Pride's father.

Lasalle hopes to avenge his brother’s murder by tracking a drug ring in Alabama he believes is responsible. Also, when Pride assists with the case, he crosses paths with Eddie Barrett (Eddie Cahill), an elusive individual who knows more than he is sharing.

When Pride is unable to sleep due to continuing nightmares about the mysterious man in the red suit, he undergoes a specialized treatment to help him figure out the man’s identity. Also, an arrogant new officer, Special Agent Quentin Carter, joins the team.

When Sebastian is injured while unsuccessfully trying to prevent a kidnapping, NCIS races to find the missing woman and her abductors; the team gets a peek into Agent Carter's personal life.

As NCIS investigates a suspicious death and the missing key piece of evidence is a top secret, high tech battery, Pride and the team realize there could be deadly consequences if it falls into the wrong hands.

The team investigates the deadly bar bombing and impending criminal turf war involving Sasha Broussard. Also, while Pride must come to terms with having Connor in his life, Carter and Hannah work to define their new relationship.