Sebastian receives a plea for help from his high-school friend Adrian Conner after her business partner is killed at the Crescent City Gaming Convention. Also, FBI Special Agent Raymond Isler believes Adrian is a hacker the Cyber Crimes division has been tracking for years.

Gregorio calls on her former behavioral science professor, when the team's latest case matches one she studied during FBI training.

While NCIS investigates the murder of a Navy intelligence officer killed during a conference for foreign diplomats, the key witness cozies up to Sebastian. Also, Pride has some trouble adjusting to his new position at the agency.

After a reshuffling of assignments, Pride is no longer Special Agent in Charge of the Southeast and returns to the New Orleans NCIS office during the investigation of a missing petty officer.

The team uncovers a sinister plot by a private detention center contracted by the government to house undocumented immigrants; Lasalle and Sebastian travel to Alabama to search for Lasalle's missing brother.

Tammy must protect Rachel, a research-obsessed teenage girl, after her father is shot in their home, while the rest of the team searches for a motive.

The team investigates the death of a Naval microbiologist whose hobby as a "myth buster" resulted in his death at the hands of a legendary bayou creature; Agent Khoury conducts an investigation into previous actions of Deputy Director Van Cleef.