Topher takes over as chief of the night shift. TC is temporarily suspended. Jordan is scrutinized for her mishandling of the man who shot a recovered Topher. A father is trapped under an elevator. Ragosa returns to the ER.

The night shift is tested when a rancher accidentally shoots his wife. TC heads to a teen party to save the life of a young football star. Jordan and Kenny treat a beauty queen in severe distress. Topher makes a decision about his job.

En voldsom bilulykke resulterer i, at et par nygifte teenagere og en ung gravid kvinde bliver hastet til hospitalet.

An injured skydiver is rescued, but there's more to the case than meets the eye. Meanwhile, the night-shift staffers treat an electrocuted janitor, then scramble to save his wife and children when they fall ill to life-threatening symptoms; and Paul learns about his limitations as a doctor.

A patient arrives with radiation poisoning, spinning the night shift into chaos and putting it into lockdown. Meanwhile, staffers speed to a serious car crash, where they discover an injured police officer, TC's troubled sister-in-law visits, and a former patient harasses Jordan.

As a thick fog descends upon San Antonio, the doctors must improvise to save the victims of a car crash; Topher, Drew and Kenny treat siblings injured in the fog.

T.C. discovers his sister-in-law's complicated history after he treats her for a fall down stairs.

A downtown gas explosion sends dozens of casualties to San Antonio Memorial Hospital.

Drew takes action when a gunman attacks at a friend's promotion ceremony.

A building collapses during a rodeo; a severely injured cowboy exhibits strange symptoms; Scott causes a serious car accident.

A boy is suffering with a serious fever and his high-strung mother begins to show signs of distress.

Drew and Paul head to the scene of a multi-car collision while the newly-anointed Dr. Ragosa along with Jordan, Scott, Krista and Kenny, manage the deluge of incoming victims. Meanwhile, TC and Topher head into a war zone to treat an old friend.

T.C. and Topher return to find Jordan in critical condition and San Antonio terrorized by snipers; Drew and Gwen get caught in the crossfire when a SWAT team corners the snipers.