Mojo Jojo unleashes a curse that turns everyone into dogs, including the Powerpuff Girls, but the three sniff out a solution and show Mojo Jojo that their bite is worse than his bark.

Professor Utonium falls head-over-heels in love for the lovely Ima Goodlady. Unfortunately, she's really the sinister Sedusa, out to keep the Girls grounded for the first time ever while she commits crimes around Townsville, such as making off with the Mayor's jewels.

The Powerpuff Girls hate roaches. Roach Coach uses this to his advantage to take over Townsville. Can the Powerpuff Girls overcome their fear of roaches?

After putting 3 criminals to jail those 3 criminals dress up as the Powerpuff Girls. Spreading crime wherever they go these impostors ruin the girls' reputation.

The heinous Him toys with Bubbles' mind by speaking to her through Octi, her favorite stuffed animal. Following Octi/Him's instructions, Bubbles provokes a fight between her sisters that prompts the Professor to issue a time-out until the Girls can make amends and make squid meat out of the giant, Him-controlled Octi.

The Amoeba Boys' ill-conceived plan to stand in front of the "Keep off the Grass" sign at Townsville Park all night in the rain leaves them with a terrible virus. When they infect the Townsville population, it's up to the Girls to find the antidote.

Buttercup becomes smitten with Ace, the leader of the Ganggreen Gang. However, when the gang exploits her infatuation and lures Blossom and Bubbles into danger, Buttercup quickly comes to her sisters' rescue and shows the boys the real meaning of the word "crush."

A squirrel trespasses on Fuzzy Lumpkins private property. Fuzzy chases him all the way into Townsville and goes crazy hurting all the citizens that stand in his way.

When all the lights go out at night the Boogie Man and his monsters come out to boogie all night long.

The Mayor tells the girls' a story about a famous magician who died by a trick with a laughing audience. Now the magician has come back to life to take out his revenge.

The Ganggreen Gang gets hold of the Mayor's hotline to the Powerpuff Girls and makes prank calls, sending the Girls on a wild goose chase all over town. However, when it's the notorious villain's Mojo Jojo, Fuzzy, and Him that the gang disturbs, they learn the price of making prank calls.

The citizens of Townsville loves The Powerpuff Girls and its annoying Him, so Him turns everyone's love for the Powerpuff Girls into hate.

There's a new man in town: Major Man, an impossibly perfect superhero who cuts in on the Girls' turf. Unfortunately, Major Man isn't as perfect as he is supposed to be as the girls soon discover, and come up with an idea to make Major Man reveal the fraud that he is in the midst of a monster attack.

Mojo Jojo kidnaps the Professor in a plot to steal the girls' powers when they arrive.

Buttercup teases paste-eating classmate Elmer. When a fly with atomic chemicals enters the paste, Elmer turns into a destructive Paste Monster. Buttercup has to get out of a sticky situation by doing something against her tough nature—apologizing.

On a very hot and humid day Blossom discovers that she has ice powers.

Bubbles is tired of people dismissing her as more sugar than spice. When she sets out to prove she's hardcore, she takes everyone by surprise, even Mojo Jojo.

Mojo kidnaps the Mayor and the Powerpuff Girls rescue him, but when the Mayor tries to get the story out of them each Powerpuff Girl has their own version.

The Mayor creates a commotion in Townsville about being re-elected as Mayor again, but he wakes up Fuzzy Lumpkins who get's annoyed. The people like Fuzzy and vote him Mayor.

The Powerpuff Girls play baseball and the ball goes into Mojo's home. They ask him to look for the ball, but Mojo takes advantage of the situation and tries to destroy them.

A clown get's hit by a bleach truck and turns into an evil mime.

Mojo Jojo creates the ultimate weapons against the Powerpuff Girls. They're Brick, Boomer, and Butch: The Rowdyruff Boys, male equivalents. When regular fighting doesn't work against the Boys, the Girls have to use their feminine wiles to seal a victory.

Worried about the Girls' safety, the Professor creates Powerpuff Dynamo, a state-of-the-art giant robot, to help them in battle. When a dynamite duel breaks out between Dynamo and a Giant Fish Balloon Monster, a parody of Godzilla or Gamera, Little Tokyo, Townsville is the stage of an explosive battle.