Sally, a bank teller deeply in debt, robs her own bank and plants evidence that implicates a fairly commonplace man who was present during the crime. Police Squad, a special unit of the police force, is called to investigate a double shooting that happened during the robbery. However, the stories just don't add up. The evidence builds and points in Sally's direction, but it's up to Frank to find the clues that will put her away.

Frank investigates a veteran boxer who lately has been throwing his fights. He takes the boxer under his wing in order to expose the boxer's corrupt manager. Unfortunately, the manger has kidnapped the boxer's girlfriend and put the boxer's title fight in jeopardy. Frank now tries to save the boxer's girlfriend in the hopes that the boxer won't have to throw the match so he can have a shot at rejuvenating his career in the ring.

The daughter of a wealthy business man is kidnapped on her 18th birthday and Police Squad swings into action. The main suspect of their investigation is the girl's boyfriend. When Frank and Ed listen to a recording of the kidnapper's demands, they hear the distinct sound of a tuba in the background, though it could also be a ship's horn. They search for a tuba store. When they do track down and find the kidnapper, the criminal fights back.

Ένας αυστηρός δικαστής δολοφονείται και οι υποψίες στρέφονται στον βομβιστή Έντι Κασάλες, που φυλακίστηκε εξ αιτίας του. Ο υπαστυνόμος Φρανκ Ντρέμπιν ξεκινά την έρευνα από την πρώην σύζυγο του υπόπτου, Λάνα, και την νυν ερωμένη του, τη χορεύτρια Μιμί Ντε Ζουρ.

Όταν μια δασκάλα χορού ξυλοκοπείται απ' τους μαφιόζους που πουλάν προστασία στη γειτονιά της, ο Ντρέμπιν και ο Νόρμπεργκ ανοίγουν κλειδαράδικο στην ίδια περιοχή για να παγιδέψουν τους ένοχους.

Ένας πληροφοριοδότης της αστυνομίας εργάζεται στο νυχτερινό κέντρο "Mr V's", που λειτουργεί ως βιτρίνα κυκλώματος ναρκωτικών. Όταν δολοφονείται, ο Ντρέμπιν παίρνει τη θέση του παριστάνοντας τον κωμικό και προσπαθεί να ξεσκεπάσει την ιδιοκτήτρια του μαγαζιού, Βερόνικα Ρίβερς.