시즌 정규 출연진 5

1. 

   마이클 쉰

   William Masters

2. 

   리지 캐플런

   Virginia Johnson

3. 

   Caitlin FitzGerald

   Libby Masters

4. 

   Annaleigh Ashford

   Betty DiMello

5. 

   Teddy Sears

   Dr. Austin Langham

특별출연 11

1. 

   Josh Randall

   Nate Bombeck

2. 

   Sarah Sido

   Francine Bombeck

3. 

   Jonathan T. Floyd

   Repairman

4. 

   Alexa Alemanni

   Maureen

5. Susie Schelling

   Scrub Nurse

6. George Mackey

   Anesthesiologist

7. Jora Senane

   Surgeon

8. Amber Marie Hunt

   Dinner Patron (uncredited)

9. 

   Barry Watson

   Shelley Decklin

10. Alex Wyse

    Elliot

11. 

    Kayla Madison

    Tessa Johnson

제작진 2