Oliver accidentally steps into the line of fire of a superhero's beam during a routine test, which reverts him back to being 4 years old. While Kaz tries to fix Oliver, Alan develops an undesirable and embarrassing power.

Kaz and Oliver are exhausted and stuck working the overnight shift during a lunar eclipse, when it is rumored that the freakiest patients come to the hospital. When Neocortex checks in with an illness that unintentionally traps people in their worst nightmares, Kaz and Oliver desperately try to stay awake and figure out how to save everyone from their nightmares.

Kaz launches a superhero fantasy league at the hospital. The heroes become obsessed with their fantasy stats and only perform saves and defeats that will boost their standings in the league.  Minnesota Vikings’ running back Adrian Peterson guest stars as himself.

It’s been a year since Skylar lost her powers, so Oliver and Kaz decide to throw her a party to celebrate their one-year anniversary of friendship. But when they learn that Skylar is in danger of losing her powers permanently, Oliver and Kaz set out to get them back.

It’s been a year since Skylar lost her powers, so Oliver and Kaz decide to throw her a party to celebrate their one-year anniversary of friendship. But when they learn that Skylar is in danger of losing her powers permanently, Oliver and Kaz set out to get them back.

Oliver and Kaz attempt to visit the Annihilator's lair to take his collection of superpowers and restore them to the superheroes.

Kaz and Oliver suspect that there could be a hospital mole that is working with the Annihilator.

Kaz and Oliver know that Skylar is evil, but Skylar doesn't know they suspect anything. They need to keep it that way or she may turn on them as well. They brace themselves until Skylar asks Oliver to the school dance that night.

A man from the future visits the boys and reveals himself as Kaz twenty-five years from now. Future Kaz warns the boys of an evil villain wreaking havoc on the future.

Oliver, Skylar, Alan and Gus leave Mighty Med to work on a school project together, and Kaz is left alone at Mighty Med while a rare and dangerous alien bug is on the loose.

When superhero Spark, a tough-as-nails teenage girl, meets Kaz at Mighty Med, they have an immediate connection. However, it fizzles quickly when she becomes overly possessive. Meanwhile, Horace puts Skylar in charge of security to keep villains out of Mighty Med.

Oliver is in charge of rehabilitating Wallace and Clyde since he believes they still have good left in them. Meanwhile, Kaz tries to give himself super powers with Skylar's help.

Oliver grapples with an internal conflict as he walks his mother down the aisle. Meanwhile, Kaz and Skylar struggle to protect the Arcturion from all the villains it beckons.