Caroline Rhea returns to welcome fourteen new players to The Biggest Loser and to host them at their stay at the new ranch. After being faced with a room of tempting food, the players discover a twist in the game - this time it's men vs. women! The women, who will always wear Red, will be trained by Jillian Michaels, while the Blue team, the men, will be put to the test by Bob Harper. Later, the new teams compete in the first challenge of the season - a competition that takes place in a jet so that the contestants can experience what it feels like to weigh nothing! At the end of this 90-minute episode, one of the hopefuls will be voted off of their team. Who will survive the battle of the sexes Biggest Loser style?

The contestants' diets are put to the test when they are told that if they eat some high-calorie treats, they will be given a letter from home. Who will be able to resist the temptation? Plus, who will win the next challenge, which deals with balance, and who will be voted off of their team?

Twelve contestants remain, as they continue to endure the pain from their injuries and the disputes from their trainers. They'll have to decide whether to continue on with the next physical challenge and resist the food temptations that continue to tempt them. Can they do it?

When the teams get a chance to go to Las Vegas, they'll have to endure some very tempting temptations. They will have to make some very tough decisions while they're there. Will they be able to resist, or will they lose it all for some cash?

As the teams continue to lose teammates, one team begins to lose their confidence. So, their trainer brings in a special visitor from the past to talk to them and help them regain their confidence once again. But will this be enough to get the team back on track, or will the team continue to fall apart, despite their trainer's efforts?

As eight contestants remain, everything changes with twists at every corner. The teams are no more, contestants are forced to work with their enemies, and even the weigh-in will have a special twist this time around. All this leads up to the most shocking elimination yet. Who will it be?

In order to participate in a professional photo shoot, all seven remaining contestants receive a Beverly Hills-style make-over. Afterwards, a special surprise awaits the seven contestants at the pedicab race when their family members arrive for a surprise visit, as they become the cargo for the race. The winner will not only receive immunity for the week, but he/she will also get to spend an evening with their family.

Caroline informs the remaining six contestants that the duos are gone from here on out. Now, they will all be competing against each other by themselves. Aside from this change in the game, one contestant will shock everyone with their new look. Meanwhile, two other contestants will end up having a fight between each other.

Before participating in the weekly challenge, the remaining men share their dreams with everyone else. This week, the challenge will prove to be one of the hardest ones yet. The contestants must hang on with their arms and legs to a tube hanging above a swimming pool. Can the remaining five contestants handle it?

Final episode before the live season finale, where the remaining four contestants discover how far they've come since their first day on the ranch. Time for one last challenge, in which the contestants will have to carry their weight in quarters, with the winner getting to keep his/her quarters.

Caroline Rhea hosts the live season finale, where ""The Biggest Loser"" will be chosen out of the three remaining contestants. The results of all their hard work will finally be revealed, with ""The Biggest Loser"" also walking away with $250,000, as well as a healthier lifestyle.