The New Orleans band Galactic perform with help from singer-songwriter Ryan Montbleau and vocalist Erica Falls. Included: "Sugar Doosie"; "Right On"; "Higher and Higher"; "Does It Really Make a Difference"; "Domino"; "50 Ways to Leave Your Lover"; "Long Live the Borgne"; "Into the Deep"; "Heart of Steel"; "Dolla Diva"; and "I Can't Stand the Rain."

British soul singer Joss Stone performs. Included: "Super Duper Love"; "Tell Me What We're Gonna Do"; "Let Me Breath"; "This Ain't Love"; "Music"; "Harry's Symphony"; "Stuck on You"; "Fell In Love With a Boy"; and "Right to Be Wrong."

Sister Sparrow & the Dirty Birds perform. Included: "Borderline"; "Sugar"; "Freight Train"; "Catch Me If You Can"; "Frankie"; "Prison Cells"; "Who Are You"; and "Mama Knows."

Memorable performances from the first five seasons are spotlighted. Among the featured artists: Los Lonely Boys; Tori Amos; Brett Dennen; Rubblebucket; Deer Tick; Tedeschi Trucks Band; Joss Stone; Galactic; Dawes; and Ani DiFranco.

Ani DeFranco performs with help from folk duo Mike + Ruthy. Included: "Shameless"; "Both Hands"; "Shy"; "Dilate"; "You Had Time"; "Angry Anymore"; "Nowhere but Barstow"; "Crime for Crime"; "Overlap"; "Which Side Are You On"; "Binary"; and "32 Flavors."

Performers serve up cover songs. Included: the Tedeschi Trucks Band ("Angel from Montgomery"-"Sugaree"); Rhiannon Giddens ("Lonesome Road"-"Up Above My Head"); Galactic with Erica Falls ("I Can't Stand the Rain"); Jackie Greene ("Scarlet Begonias"); Joan Osbourne ("Rhymes"); Wilson Phillips ("California Dreamin'"); the Bacon Brothers ("Givin' It Up for Your Love"); Tommy Emmanuel ("Classical Gas"); and Rusted Root ("Suspicious Minds").

The Season 5 finale features Melissa Etheridge.