Teenage suspect Traci Sands dies in police custody after being arrested for the murder of the man who reported her to child protective services. Rodgers reveals that she died because someone outfitted her with a benecrine I.U.D. that reacted with Sands' sickle cell syndrome and ended up killing her. Fontana and Green follow the trail to a charitable clinic and nurse Gloria Rhodes, who believes she is saving the world by sterilizing women that she does not believe are worthy of having children. McCoy faces former assistant district attorney Paul Robinette in court as Robinette defends Rhodes.

Green and Cassady hunt a mass murderer Leon Vorgitch, who recently escaped from prison. The finally corner Vorgitch in a school with a room full of hostages, and before surrendering himself to police, Vorgitch shoots a number of innocent children. His unwillingness to accept a deal infuriates McCoy, as it gives him more time to escape prison again. When the father of one of his victims takes justice into his own hands and ends up being used as a campaign slogan for a local politician, McCoy and Rubirosa try to convince Robert Purcell not to let himself be a scapegoat for a political platform.

An NYPD officer kills a troubled fellow officer who took hostages at gunpoint; detectives Lupo and Bernard find valuable stolen documents and a dead body at the man's apartment.