Ethan, now a prisoner under the watchful eye of Scotland Yard Inspector Rusk, is on a train speeding through the desert of the American West. Meanwhile, Sir Malcolm is confronted by a mysterious Native American man in Zanzibar. Back in London, Dr. Frankenstein seeks out his old friend Dr. Jekyll and Vanessa seeks the help of Dr. Seward to battle a new evil.

Lily and Dorian pay a visit to a most unusual show, and Vanessa invites Sweet to a different show. Rusk sets out to track down Ethan and make sure that he hangs, and Henry demonstrates the efficacy of his potion for Victor.

Vanessa asks Seward to hypnotically regress her after learning that she met the Master sometime in the past. Rusk learns that Ethan has a new ally. Caliban finds his wife and child. Lily and Dorian have Justine pledge her service to them.

Through hypnosis, Vanessa relives what happened to her in the Banning Institute, including the man who befriended her... and the spirits who tormented her.

Hecate and Ethan try to survive in the desert wasteland, as thirst and their unrelenting pursuers take their toll. Meanwhile, Victor and Henry continue with their work in Bedlam.

Vanessa turns to old friend Ferdinand Lyle for help, who introduces her to a new ally. Meanwhile, Lily, Dorian and Justine put their plan in motion; and Ethan, Sir Malcolm and Hecate arrive at Jarod Talbot's ranch.

Ethan, Sir Malcolm and Kaetenay return to London, where Ethan searches for Dr. Frankenstein. Dr. Seward discovers Renfield's secret. Lily reveals a heartbreaking story from Brona Croft's past.

Season finale. Ethan learns the shocking truth about Kaetenay. Dr. Seward uses hypnosis on Renfield. Meanwhile, The Creature must make a moral decision as Sir Malcolm, Ethan, Kaetenay, Dr. Seward and Catriona battle to save Vanessa.