London 1891. Renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them search for someone who has been lost.

Vanessa and Sir Malcolm encounter the mysteriously beautiful Dorian Gray at a party. Things take a turn, however, when renowned medium Madame Kali hosts a seance. Meanwhile, Ethan befriends Ms. Brona Croft, a young Irish immigrant.

Dr. Frankenstein is confronted by his past. Vanessa has a vision of Mina, which leads to a strange discovery at the London Zoo.

Vanessa's infatuation with Dorian Gray grows. Professor Van Helsing is hired to work with Dr. Frankenstein. Fenton draws his master to Sir Malcolm's mansion.

Vanessa recalls her past and the events that ultimately lead to Mina's disappearance.

Vanessa's latest vision leads Sir Malcolm, Ethan and Sembene on a search. Professor Van Helsing reveals more details to Dr. Frankenstein about who has taken Mina.

Over the course of four harrowing weeks, Sir Malcolm, Ethan, Dr. Frankenstein and Sembene do everything they can to save Vanessa from what's within her.