James "Ghost" St. Patrick forms a dangerous alliance with his brother-in-arms, Tommy, and his mortal enemy, Kanan; Angela is implicated in murder and turns to an unlikely ally; Tasha enlists LaKeisha to protect Tariq.

The St. Patrick family grieves Raina while the AUSA's office discusses taking down "Ghost" and ending Angela's career. Councilman Tate exploits Raina's death. Dre maintains order within his organization.

Ghost and Tasha butt heads on how to grieve. Angela pursues the Jimenez Cartel while Kanan goes after Dre's organization. Tommy confides in LaKeisha about his relationship with Teresi, complicating everyone's lives.

Tensions run high when Jason returns. Ghost warns Tommy about Teresi while he hatches a plan with Kanan to rid Tommy of his new family. Angela gets closer to arresting the Jimenez Cartel. Kanan forms an unlikely alliance.

After his spiritual awakening with Rev. Macedon, Ghost confesses his sins to Angela. Angela preps Tasha for Federal questioning and Ghost must break his business deal with Tommy when Truth is audited by the IRS.

Ghost, Tommy and Kanan move forward with their task to kill the heads of the Jimenez Cartel. Donovan warns Angela that her own office is after her. LaKeisha lets slip that Teresi is Tommy's father.

The AUSA turns up the heat on Ghost and implicates his inner circle in on a RICO; Ghost and Tommy plan to frame Dre for the murder of Raymond Jones, Raina's killer; Angela and Tasha enact a plan of their own.

When Angela's arrest of Jimenez gives her a solid win, she discovers plans that would undercut her career; Ghost tasks Tommy in killing a snitch, changing all of their lives; Tariq accepts the consequences of his choices.

When the RICO case comes crashing down, Angela breaks ranks to form her own A-team. LaKeisha takes a stand of her own while “Ghost”, Tommy, Tasha, and Angela race against the clock to prove their innocence...but to what end?