Dr. Brenda tries to save a calf with a dislocated hip. Dr. Pol helps a hedgehog and a retired stallion and then judges a chili-cook off.

Dr. Brenda's 21-years working at the clinic is taken a look at. A horse receives help with weight management whilst a dog with a stomach wound is helped.

This fall, love is in the air at Pol Clinic as Charles plans a surprise anniversary getaway for his parents. But the Pols aren't giving just their marriage some TLC; there are sick animals across central Michigan that need Dr. Pol before he can get out of town and celebrate 46 years of marriage with Diane. First up is a bellowing, bloated calf with a problem much worse than a bellyache. Meanwhile at the clinic, Dr. Brenda is dealing with a snarly dog that has a gnarly hot spot on his cheek. Still, every so often a client comes in that stops everyone in their tracks. Today it's a beloved family cat suffering from a severe gunshot wound. From dachshunds to Rottweilers, sore husky pups, and to an abandoned pit bull.

This week, the Pols go Dutch when a special visitor comes to town - Charles' uncle Jan is visiting from the Netherlands! Uncle Jan doesn't speak English and Charles is on a mission to learn enough Dutch to finally have a conversation with his uncle. Dr. Pol helps when he can, but he's got to stay focused on the job while dodging a feisty cow with a stinky foot problem and helping a down-cow taking a treatment that could kill it. Brooks, a puppy with a protruding hernia and Buddy, a Shih Tzu with a bulging eye who's seen better days, keep the clinic hopping until Uncle Jan is in Michigan. Will the conversation be lively or Charles find his attempts fall flat on Dutch ears?

The Pol Clinic is bursting at the seams with two-legged and four-legged traffic, and Dr. Pol and Diane are ready to expand. Cement mixers and cranes have the Pol clinic buzzing with anticipation for this latest addition. But on the road it's business as usual for the crew as Dr. Pol, Charles and Dr. Brenda tackle the problems of a feisty alpaca, a troubled twosome of dairy cows and a miniature donkey with a fungus problem on its feet.

This Thanksgiving the birds are calling the shots at Pol Veterinary Services when Charles adopts three turkeys that are on the run. Then when Gail and Lynn Wernette find a pair of wandering Great Danes near their home, they bring them to the clinic. Thin and in poor health, these dogs are in need of some serious TLC, but Dr. Pol and Diane have a full house. The hunt is on for homes for these gentle giants. Later, it's all hands on deck when Capone, a horse with a nasty cut on its hoof, arrives in the clinic parking lot. It's an uphill battle as Dr. Pol wrestles with Capone, and calls for help from his owners to get the horse treated. It wouldn't be Thanksgiving without a meal shared with family and friends and everyone from the clinic gather for a traditional Amish Thanksgiving meal, taking a break from the business of work to enjoy one another's company.

Twas the week before Christmas and all through the farms, Dr. Pol is still working inside the red barns! It's beginning to look at lot like Christmas in Michigan as Dr. Pol heads to John Jourdain's for his first farm call of the day. Without a head chute, the set-up for these castrations is less than ideal - but nothing Doc Pol can't handle. It's clear these calves aren't willing to surrender without a fight. Meanwhile, Dr. Brenda races out to Rooftop Landing, where a reindeer named Ole is aching for a chance to pull Santa's sleigh. December ‘tis also the season when reindeers breed, leaving this buck cruising for a mate, and on his feet almost all day long. This wouldn't be a problem if he didn't have a massive hoof abscess growing on his back right hoof. Will Dr. Brenda be able to get Ole's hoof healed up in time to join the reindeer games? The end of the week finds the Pols in the mood for some holiday cheer. With Dr. Pol and Diane as Grand Marshalls of the Farwell Lights Parade and Charles volunteering as Santa's helper elf - the family can finally celebrate the Christmas season together.

It's a full day for the vets when Dr. Pol wrangles a foursome of gutsy cows that refuse their pregnancy checks and Dr. Brenda deals with an after-hours emergency when Sisco the horse is down with colic. The two vets are always ready for action, but with the clinic understaffed and Dr. Sandra preparing to leave the practice, life at the Pol Clinic somehow found a way to get crazier.

Halloween-themed episode in which Dr. Pol tends to the needs of a variety of animals. Included: cows; sugar gliders; horses.