Construction workers have inadvertantly released Achira, a ghost that can spread disease. The only ones who could stop this ghost are the Ghostbusters, but they have long since disbanded. In fact, only Egon is still in New York City. He is now teaching a college class, but his four students may prove very helpful against this nasty ghost.

Egon builds new and improved ghost busting equipment for the new team. While they search for Achira, Eduardo again sees Kylie, who has been possessed by Achira.

A Rabbi's son creates a Golem to defend against temple vandalism. But the Golem grows to strong to be controlled, forcing the EGB to come up against this violent force.

The EGB will have to face their inner demons when they come up against a ghost that can bring people's fears to life.

Characters from a horror novel are attacking innocent people.

A thief has gotten ahold of a pouch containing ancient runes, which a demon uses to enslave innocent people in his realm. The EGB have to catch this thief and rescue the demon's slaves.

A demon takes control of Roland and forces him to build a deadly mechanical host vehicle.

The EGB are on a job to bust a ghost, when they find the ghost is the house they're in and intent making two trapped children it's next meal.

Ghostly clowns are on the loose and feeding on laughter. Eduardo traps one of them, but then he starts to turn into one of them.

Everytime someone looks at the strange orb, a ghost appears to steal their eyes. Problem is, a museum is about to put the orb on display.

Janine attempts to make Egon jealous by going on a date with another man. Unfortunately, the man she dates is a bug demon in disguise and looking for a queen.

Ghosts are rampaging through the city and the EGB's equipment can't stop them. But a mysterious Piper claims he can.

A ghost capable of granting wishes comes to town in the form of a salesman, only his results are far from what people wanted. Eduardo unfortunately becomes his latest victim when he gets placed inside Kylie's cat.

A gremlin is on the loose, causing trouble throughout the city. While working to catch this gremlin, the EGB are arrested.

The equipment-less EGB have to protect a small town from the Jersey Devil.

A ghost capable of sucking all the water out of people is on the loose.

The EGB's hunt for a Banshee gets complicated when the Banshee's sister puts a spell on Roland.

Kylie gets transported to a future where a ghost named Tempus rules over humanity. While she meets a group of resistance fighters, the others have to prevent Tempus' take over in the present.

The weather in New York City is made a lot worse when a spirit called the Harasvelg arrives.

A Demon seed inhabits a Professor's plant, and takes over the building. The plant is destroyed, and the demon takes on another plant, in the park. Kylie thinks this demon is a helpful Amazon Plant, however she is wrong. It's really a civilization destroying demon inhabiting a seed. Can the EGB's stop Kylie before she has a chance to freeze it and send it back to the Amazon?

A recently released Leprechaun is trapping people in his pot of gold and Mayor McShane is his next target.

A ghost starts taking over people's bodies by pulling their souls into a mirror. When the others get trapped, it falls to Kylie to save the day.

Slimer gets trapped in the containment unit (and Peter Venkman isn't even here to see it), surrounded by some very vindictive ghosts that remember him, including a demon named Surt who wants to bring about Ragnarok. Eduardo goes in to save Slimer, while the rest of the EGB has to bust a demon hound in the Firehouse.

When Kylie was a child, a friend of her's mysteriously disappeared. Now, a ghost who looks like him has turned up. To stop and save him, Kylie calls upon a ghost the Real Ghostbusters captured years ago: the Grundel.

The EGB find their nightmares becoming more real when a ghost tries to leave the dream world and enter ours'.

The EGB have to join forces with a vengeful ghost to stop a ghost whale's rampage.

The EGB find their equipment useless against a radioactive energy eating ghost.

After a Chinatown merchant disappears, the EGB find the merchant has fallen prey to a bone stealing demon.

The EGB protect a man from a ghost that's looking to make a husband out of him.

The EGB have to contend with a ghost, whose victims go on feeding frenzies, looking to take over the world.

A reopened oil mine sets a ghost, that can possess vehicles, free.

A demon dog is enslaving all the dogs in the city. The EGB not only have to face that but also the demon dog's master.

There's been a string of power outages and the blame is falling to a group of people that live under the city. A young girl from the group gets help from the EGB, who find lightning demons are the real cause.

With Janine on vacation, the EGB hire a temp. But this temp is really an energy draining ghost planning to destroy the team.

Egon moves in with Eduardo while the Firehouse is sprayed for bugs and learns Eduardo hasn't told his brother what he does for a living. Meanwhile, the EGB go up against trolls with the power to replicate.

An old colleague of Egon's turns out to be behind a rash of ghost crimes.

The old team sticks around to help battle a mysterious entity that is heading to New York from the Bermuda Triangle and devouring everything in its path.

A sphinx starts tampering with people’s minds when they can’t find a way to answer the riddle.

Three teenage witches try to bring Kylie into their circle.