Efter at være blevet bortført af Katarina Rostova, er Raymond "Red" Reddington havnet i ukendt territorium, og er usikker på hvem han kan stole på.

Liz, Dembe og taskforcen fortsætter deres søgen efter Red. Red forsøger at flygte med hjælp fra en uventet allieret, men indser at han ikke er Katarina Rostovas eneste mål.

Aram går undercover for at infiltrere et hemmeligt selskab bestående af rige adrenalinsøgere, som underholdes af opsigtsvækkende voldshandlinger.

Coopers moralske kompas testes, når en officer, som han tjente med som ung mand, længe antaget at være død, dukker op igen som en krigsfange.

Liz og teamet efterforsker en berygtet snigmorder er kendt for at anvende biovåben. Red og Dembe rejser til Cuba for at finde ledetråde, og Aram overvejer et nyt forhold.

Red gør FBI opmærksom på, at en forsker der arbejdede med kunstig intelligens, er død under mistænkelige omstændigheder. Imens bliver Francesca viklet yderligere ind i Red's kriminelle aktiviteter.

Red og Dembe holder øje med en person som står Katarina Rostova nær, mens hun utilsigtet involverer Agnes i sit eget projekt.

Red er desperat efter at får at vide hvor en gammel bekendt befinder sig, og sætter teamet til at finde en person som specialiserer sig i usporlige pengeoverførsler.

Red and Liz investigate Orion Relocation Services, an organization that surreptitiously facilitates the disappearance and relocation of criminals. Meanwhile, Katarina delves into the memories of an old friend in order to get additional information about the Townsend Directive.

Red and the Task Force pay a visit to a former blacklister, as an explosive confrontation leads Liz to make a critical choice

With the help of the Task Force, Red tracks a gifted art forger who has thwarted his plans to sell stolen pieces. Aram’s love life becomes increasingly complicated. Liz and Ressler confide in each other.

Secluded on a private island, Red reunites with an old flame and a ring of thieves in a plot to make millions off stolen art. Plans are quickly derailed, however, when guests on the island mysteriously show up dead.

The Task Force investigates a series of attacks on data centers perpetrated by a blacklister with a peculiar condition, as Liz conducts a secret investigation on the side. Meanwhile, Glen desperately tries to prove his value to Red after a shipping mishap.

A Blacklist case becomes personal for Agent Park when the team investigates a mysterious disappearance in the Alaska Triangle. Meanwhile, Aram enlists Red’s help to find out what really happened to Elodie’s husband.

A blacklist case forces Liz to choose sides between Red and the Task Force. Meanwhile, Red tries to calm a panicked Ilya Koslov, who believes he is under surveillance.

Liz and the Task Force take on a cold case that may have some new victims. Meanwhile, Red tries to help a friend of Dembe who is in danger.

As the Task Force investigates a kidnapping executed by seemingly impossible abductors, Dembe lands in a perilous situation. Meanwhile, a recent health scare causes Red to think about a successor.

The Task Force investigates an accountant who works for lucrative criminals in order to find the violent and thuggish brothers hired for his protection. Meanwhile, Liz must make a momentous decision.