The ladies are back and life in the A has changed. With Covid and a racial reckoning happening all around the ladies continue to push forward. Toya, fully moved into her dream home struggles with Dr. Eugene working long hours at the hospital, while she’s stuck at home with the kids. Contessa and Scott bicker over working together in their new private practice office, while Jackie and Simone, struggle to understand their fractured friendship. Heavenly throws a 50th birthday party for Damon, but tensions flare when the group comes together for the first time in months.

Simone and the doctors continue the fight against Covid-19 on the front lines. Contessa vents to Jackie about her and Scott’s marital problems. Toya's frustration over homeschooling kids continues. Heavenly shares some shady gossip with Quad. During Anila’s traditional Rahki party for her friends and family, Toya and Contessa's old feud reignites.

Simone prepares to send Michael off to college with one last Kids v. Adults basketball game. Anila wants to impress her parents with her new home, but momma isn’t impressed. Eugene calls Toya out for her recent cranky behavior. After an epic basketball showdown, Heavenly and Toya go into overtime, exchanging heated words.

Toya distances herself from the group and hosts her own pool party, with surprise guests. Contessa and Scott vent to others about their marital woes. Heavenly encourages Jackie to mend fences with Simone. Anila and Kiran find their dream house turning into a nightmare. Simone and family send Michael off to college with a tearful goodbye.

As the tension between former best friends Jackie and Simone reaches new heights, their husbands try and talk sense into them. Heavenly gets an unexpected call for a once-in-a-lifetime opportunity to help a young protester. Contessa enlists her niece Paris to throw a healing crystal event for the group. However, Toya brings along some blasts from the past to crash the party.

The Doctors and Wives head to Washington DC for their most important medical mission yet as Ambassadors to the March on Washington. Reverend Al Sharpton and Ben Crump come by for dinner to discuss race relations in America. And tensions brew between the doctor's and the wives as Kari reveals to Toya and Anila that Heavenly and Contessa have been questioning their intelligence.

Everyone gathers to relax by the pool prior to the March on Washington but can’t drown out the drama when Toya makes a splash and confronts Heavenly and Contessa. The doctors take a stand against the pandemic and systemic racism when they perform covid testing at the March on Washington. Later, after a day of unity, the ladies head to dinner but ditch two of their own.

After a successful medical mission in DC, the group heads home to Atlanta, reinvigorated. While Simone sees a patient with fibroids, Damon and Heavenly discuss the significance of the March on Washington with their kids during a family dinner. Toya confronts Anila about her finances. Contessa has a business consultation with a specialist before the grand opening of her new practice. Jackie plays peacemaker, hosting a dinner at her house, where Quad and Heavenly come head to head over an emoji incident.

Everyone’s lives come to a halt when they have to isolate for 14 days. Toya discovers that Quad and Heavenly can't stop talking about her. Heavenly questions her son’s investment decisions. Simone thinks about adding to the family. Jackie surprises the ladies with a porn star, but Toya gets the real surprise when Anila confronts her about the rumors Toya's been spreading.

Toya finds calm at home even as her friendships remain rocky. Simone gives her son Miles an ultimatum. Anila finds a new job in an unlikely place. Contessa opens her new practice, but it’s the same old issues with Scott. Quad throws a game night party at her home, but the fun turns to drama, as Toya is forced own up to her past words about Quad’s house.

Anila and Quad bond over their shared issues with Toya. Simone and Contessa try to get to the bottom of Toya's problems with the group. Simone and Cecil host a couple's dinner, and are shocked to learn just how fragile Scott and Contessa's marriage is. Anila hosts a Holi event in hopes to heal some of the friendships within the group but things go Holi wrong when old feuds flare up.

Cecil and Eugene hang with Scott, who shares some interesting pics on his phone. Anila checks in on her house build and learns some upsetting news about her daughter. Heavenly and Zach put the final touches on their new rental property. Contessa uncovers some truths about herself. Simone plans a political town hall event, but things go off the rails when she discovers Lisa Nicole has been trying to push her aside.

The Town Hall Event is threatened when Simone learns some disturbing info about Lisa Nicole on the local news. Anila goes to Jackie for advice on her fractured friendship with Toya. Scott reveals a bombshell to Contessa that could undermine their entire marriage.

The ladies finally arrive to Jekyll Island. Heavenly and Toya come together in hopes of starting anew, while Contessa confides to Jackie and Quad about her suspicions of Scott. The ladies relax at dinner, but their peaceful night is soon disturbed when Anila stirs the pot over a bad deal with Lisa Nicole. [Part 1 of 2]

In the season finale, the ladies enjoy a day of sightseeing that leads to some close encounters. Anila finds a creative way to get her money from Lisa. Later, the men join the ladies for the last night on the island. The truth about Scott and Contessa finally comes out, but will it create more questions than answers? [Part 2 of 2]

Host Andy Cohen reflects on some of the season’s biggest moments as the ladies of medicine come together in part one of the explosive three-part Married to Medicine Reunion. After sharing how Covid flipped their world upside down, Quad graces the stage and shakes things up with Toya when she brings up the heated Instagram live debate. Anila and Toya’s friendship is tested, while Heavenly and Toya share a special kiss. Contessa reveals shocking information about her marriage to Scott. [Part 1 of 3]

Scott crashes the stage when he hears Contessa’s reveal of their relationship status. The women question Scott’s fidelity, and Contessa has a breakdown backstage. Simone and Jackie’s friendship is questioned, while Simone is brought to tears over her hostile relationship with Heavenly. The men take the stage and Scott is caught in a web of lies leaving everyone scratching their heads. [Part 2 of 3]

The women join the stage and share how difficult this past year has been for all of their marriages. Dr. Eugene breaks down sharing the reality of life in the ER. The ladies joke about the shade they’ve thrown, but Quad takes it to the next level when she confronts Toya about the comments she’s made about her home. [Part 3 of 3]