Quad’s marriage problems are plastered all over social media and the blogs, and instead of leaning on the ladies for support, she gives them the cold shoulder. Toya tries to encourage Eugene to live a healthy lifestyle, Contessa struggles with being a stay at home Mom. Simone throws a leather and lace party to reclaim her sexy, but tensions flare between Heavenly and Mariah when Mariah claims to have receipts on "Daddy."

After Mariah accuses Damon of infidelity, Heavenly channels her rage by seeking help from an anger management therapist. Contessa worries about her father's failing health, and tells Scott she wants him to visit. Isolated from the entire group, Quad hangs with her new besties from her talk show and vents about her marital woes. Simone and Cecil continue to struggle to fix their broken marriage, while Toya throws a surprise party for Eugene, but ends up making the party all about an absentee Contessa.

When her ailing father visits, Contessa discovers his health is even worse than she thought. While Mariah has a real talk with Lauren about growing up and getting ready for high school, Simone faces a hard talk with her son, Michael about the current state of her marriage. Heavenly attempts to bring Quad back into the circle of friends for a crab boil, but everything comes to a boiling point with the women as friendships and loyalties are questioned.

Things continue to heat up at the crab boil when Heavenly and Mariah’s long-standing feud reaches a fever pitch. Quad opens up to the group, but will her words be enough? Contessa has a candid conversation with her father about a life-altering decision. Meanwhile, Dr. K encourages Heavenly to dig further into her past. Later, Jackie’s plan to reconnect her friends forces them to get up and get moving, with surprising results. 

Quad has a heart-to-heart with Jackie over her marital issues while the guys have a much-needed night to themselves where Greg tells his side of the story. Contessa takes the first step towards a new life. With Simone and Jackie in tow, Heavenly travels to her childhood home in Miami to seek out the root of her anger.

Heavenly continues her spiritual journey in Miami with the aid of Jackie and Simone. Back in Atlanta, Contessa goes through with her double mastectomy. Quad turns to old friends for comfort in her crumbling marriage. Toya and Eugene are in awe of the progress of their dream home. Mariah and Aydin take Lauren out for a dinner to explain the birds and the bees.

Heavenly, Jackie, and Simone settle back into daily life after their trip to Miami. Simone welcomes her son home from college but isn't so welcoming to the idea of Cecil moving back in. Contessa is recuperating from her prophylactic mastectomy and receives a house call from her good friends, Mariah and Dr. Jarret. Quad lunches with her mom and aunt and reveals that her life has been turned upside down. Jarret invites all the ladies to her newly constructed home for a housewarming party and Quad debates revealing her big news to the ladies.

While Mariah receives some bad news from her husband, Simone finally has some good news to share about Cecil. Heavenly reflects on her Miami trip with her therapist and makes some new personal discoveries. While Quad is quietly adjusting to her newly single life, the other women are shocked to find out through social media of Quad's divorce. In an attempt to reunite the women and bring Black Girl Magic back to the group, Jackie throws a slumber party.

Toya and Eugene contemplate celebrating their 10-year anniversary with their friends overseas. Meanwhile Jackie and Curtis celebrate, coming back from the brink of divorce and making it 17-years. Mariah plans a Black Love party but when some of the invitees fail to show, they put a damper on the festivities.

Everyone heads to Antigua for the annual couples trip. Trying to cope with divorce Quad breaks down revealing she saw Greg the night before with another woman. Contessa tries to enjoy the island sun as she recovers from breast surgery, but a surprise encounter with Toya may get in the way of that. Later things heat up when a tiff over Quad sends Heavenly and Mariah into an all out island brawl.

On Part 2 of the couple’s trip in Antigua, tensions continue to rise in the group. While Toya confronts Contessa for hitting her on purpose, Mariah can’t let go of Heavenly insulting her mom. Jackie attempts to lead a reconciliation between all the ladies but the second night dinner proves to be just as explosive as the first. Tears are shed, and everyone has reached their boiling point.

Smooth sailing turns to rocky waters when Simone and Contessa’s argument turns ugly in Antigua. Facing increased pressure, Mariah apologizes to Damon for the infidelity rumors she's spread. In order to right last year’s wrongs from Couples' Therapy, Heavenly sits on the hot seat. Determined to give back, Jackie volunteers the group for a meaningful Medical Mission as Quad hurls the hurt over Dr. Greg’s infidelities out to sea.

Simone and Cecil share some surprising news at their Mi Casa Es Su Casa Party. Determined to keep the romance going, Jackie enlists Simone and Heavenly to help her cook a meal for Curtis. Toya and Eugene visit the construction site of their new home where she discovers some unsettling news. The guys invite Greg to a men’s only outing, getting all the tea about what really went down when Quad moved out.

Realizing her baby is growing up, Mariah surprises Lauren with a wardrobe makeover. Simone and Cecil's romantic dinner date is ruined when issues from the past push Simone over the edge. Meanwhile, Jackie and Curtis struggle to compromise on a new home and a fresh start. Toya plans a wine tasting trip for the ladies that turns sour when lingering issues with Contessa come to a head and Mariah gets some scary news about Aydin's health.

Host Andy Cohen reflects on some of the seasons biggest moments as the ladies of medicine come together in Part 1 of the explosive three-part Married to Medicine Reunion. Simone reveals what her home life is really like; Contessa finds herself cornered, defending her surgery from attacks. Heavenly and Mariah try to settle an argument, leading to a dramatic confrontation. Quad lays out a shocking accusation. [Part 1 of 3]

The reunion continues as Andy tries to get to the bottom of Quad's scandalous accusations against Mariah. Then, the husbands tell their side of the story. Damon defends himself against cheating allegations, while Aydin sticks up for his wife. Later, Greg and Quad come face to face for one last confrontation. [Part 2 of 3]

The reunion concludes in part three, as Quad and Greg face off, revealing the shocking truth about their marriage. Then, as the group deals with the fallout from Quad and Greg's confrontation, divisions are drawn. Later, Toya and Contessa's friendship comes to head. [Part 3 of 3]