公元 2000 年，东都大学附设医院的脑外科医生南方仁帮一个看不清面目的人动了手术取出脑中的畸胎瘤，并因这个病人意外跌落阶梯，回到文久二年（公元 1862 年）。在幕末，南方仁遇见了在时代潮流中求生的平民，也邂逅许多名留青史的大人物。自此，偌大的历史画卷逐渐铺现。以仁在医学所的浮沉及自立门户后的众多医疗事件为主线，不仅坂本龙马、胜海舟、绪方洪庵等人物悉数登场，仁更邂逅了与自己在现代的未婚妻样貌惊人相似的美丽花魁野风。深感命运神奇的仁在试图将现代医疗技术引入江户的同时，也努力扭转着历史洪流中众人命定的走向。

超越時空、愛與生命的感人故事

〜現代腦科醫生來到動盪的幕末時期……

歷史的指針現在開始移動！人只能由人來拯救！

"에도 막부 말기의 역사는 뇌 의사에 맡겨진다.", "모두가 웃고 빛난 그에도에"

The story follows a brain surgeon named Minakata Jin who has spent the last two years in anguish, as his fiancee lies in a vegetative state after an operation he performed. One day, he faints at the hospital and awakens to find himself transported back in time to the Edo Period. He is soon attacked by a samurai, but he escapes with the help of a man named Kyotaro. Kyotaro suffers a serious injury to the head while trying to protect him, but Jin manages to save his life despite a lack of proper medical equipment. Because of that, Kyotaro's sister Saki begins taking an interest in Jin and becomes his assistant. Meanwhile, Jin is determined to find a way back to the present.

村上もとかの人気漫画をドラマ化した感動巨編「JIN−仁−」第1期。ある事件がきっかけで江戸時代にタイムスリップした現代の脳外科医が、自らも幕末の動乱に巻き込まれていく。波乱の人生を送る主人公・南方仁を演じるのは大沢たかお。仁の現代での恋人・友永未来と、江戸・吉原の最上級位の花魁・野風の二役を演じるのは中谷美紀。幕末の江戸で仁の世話をし、公私共に支えになる武家の娘・橘咲を綾瀬はるか。さらに、仁とも深く関わっていく歴史上の人物・坂本龍馬を内野聖陽が演じる。