A day's worth of trauma takes its toll on the men and women of the ER. Dr. Greene looks into leaving the ER and joining private practice. Among other events, multiple casualties are brought in when a building collapses. New medical students report for duty, including Dr. Benton's new trainee, the young and inexperienced John Carter.

Carter trains one of Benton's new students, Deb Chen. Hathaway has her hands full with an emotionally challenged patient who's obsessed with colors. A sociologist provokes people to measure their reaction times for a study. Kayson brings charges against Susan in the Vennerbeck death, leading Morganstern to question Susan's assertiveness. Benton and Walt hunt for Peter's missing mother.

Dr. Hicks berates Benton when he tries to switch shifts to attend his mother's birthday party. A teenage girl, a frequent patient of the ER, is brought in for a drug overdose. Carol decides she wants to adopt Tatiana while Tag isn't so sure. Dr. Ross slugs an abusive father in the lobby. Jen accepts a job offer in Milwaukee despite Mark's offer from Morganstern. Deb and Carter await the arrival of sub-internship applications.

Mark tries to find a way to tell Rachel about his impending divorce. Benton attends a banquet at Vucelich's home, with Jeanie as his date. Carter finally tells Mr. Rubadoux about his wife's terminal condition, making the man furious. Morganstern is admitted to the hospital after breaking a leg at a Scottish family reunion.

Mark is riddled with self doubt as the hospital prepares to settle the O'Brien suit. Kerry appoints herself as Susan's personal mentor. Carol mind a bucketful of expensive worms. Doug balks at counseling a teenage boy who thinks he might be gay. Benton uncovers some disturbing information concerning Vucelich's study. Carter steals a diagnosis from Harper.

Benton decides to blow the whistle on Vucelich's unethical study methods, causing Vucelich to drop him from the study. Susan treats a street couple, one of whom has passed HIV to the other. Doug receives a visit from his estranged father. Carter spreads rumors about an affair between Mark and Susan. Mark buys a motorcycle. Prostitute Loretta has cervical cancer.

Carter engages in competition with new surgical resident-in-training Dale Edson upon learning that residents will be evaluated and graded; only the top ones advancing to second year. It doesn't help that Dale once had a relationship with Harper. Mark flirts with infomercial director Iris. Peter faces the fallout from his altercation with Doug when surgeons begin dropping him from procedures. Shep begins exhibiting uncontrolled hostility, first to a patient being abusive with Carol, then a pedestrian. Susan and Chloe try to reach an agreement regarding Little Susie.

Encouraged by Carol, Mark finally asks Susan out. Benton tries to save a boy, despite the fact Doug thinks he's brain dead.

Carol has to fire two of the nurses. Meanwhile, Gant feels Benton is too hard on him.

Carol will hear whether her suspension is permanent or not. Mark and Doyle do what they can to get a patient with Down syndrome on a heart transplant list.

Carol would like to have a women's and children's health care clinic within the ER. Benton has trouble combining work and fatherhood.

Benton has a very extraordinary and interesting case when he comes across a boy with reversed internal organs.

Dr. Corday's father visits from overseas in an attempt to convince her to join his medical practice. Weaver suggests that Elizabeth look into alternative methods to stay in America, like starting over as an intern. Weaver also doesn't let an opportunity pass to remind Doug of the way he bypassed her authority in the McLean case. Lucy continues learning, earning more of Carter's respect than she deserves. Peter takes Reese in for another hearing test. Mark has several discussions with paramedics about the state of the EMT program. Carol hires a nurse practitioner to help out in the clinic. Carter is having trouble being an RA in the dorms.

Dr. Corday commits a deadly error after being on-call for nearly 36 hours straight. Peter visits Dr. Kotlowitz and receives encouragement regarding a cochlear implant for Reese. Dr. Amanda Lee, a prospective new ER chief, visits. In the wake of a failed pregnancy attempt, Carol lashes out at a mother using abortion as a means of selective birth control. Carter and Lucy feud when Carter accidentally uses her palm computer and finds out what she thinks of him. Mark panics during a paramedic initation.