When is it time to go out on a limb? Armand Assante guest stars as a patient who makes Sam an offer she might not be able to refuse. Luka must calm Abby’s baby-related fears after an incident at the hospital places everyone at risk. Kerry makes a difficult choice, and Neela joins a support group.

Abby and Luka desperately try to keep a young woman brought into the ER with stab wounds to the neck alive. As her condition begins to worsen, Clemente steps in and tries a risky procedure on the girl in order to save her life. Meanwhile, Neela pulls an all-nighter in preparation for a speech at a surgeon's convention, Ray treats a man claiming to have swallowed a bottle of pills, and Sam decides to take a part-time job with Richard to help her with childcare expenses.

When Luka answers a call for help, he discovers not everyone is pleased. Will he honor his commitment, or ask a colleague to step in for him? Abby and Morris wrestle with the strange case of a car crash victim. Having made a change in her life, Sam finds herself enjoying a few new perks. Neela has unexpected visitors, with even more unexpected news.

As Abby and Luka cope with their newborn's life and death struggle, the couple is shocked to receive a surprise visitor: Abby's mother Maggie. Meanwhile, Sam fears the prospect of criminal charges; Neela discovers that Tony Gates will be joining the ER team as an intern and Morris gets his job back while Weaver gets demoted.