Marge pensa sia giunto il momento di separarsi da Homer. Quest'ultimo, dopo un iniziale senso di smarrimento, inizia una nuova relazione con una donna più giovane.

Un noto chef televisivo sfida Homer a un barbecue. Ma prima della gara, la speciale griglia da utilizzare nel corso della trasmissione viene rubata.

Upon learning that their father really died of lung cancer, Selma and Patty agree to quit smoking. When Selma relapses, an angry Patty moves in with Marge and Homer.

When Lisa becomes scared at the Krustyland Halloween Horror Night, Homer is forced to take down his Everscream Terrors decorations. Halloween pop-up employees seek vengeance on Homer for causing them to lose their jobs, and rob his house while Homer and Lisa hide out in the attic. Homer and Lisa light up their stored holiday decorations to attract attention and stand up to the intruders.

In the annual fright fest Halloween episode, Sideshow Bob finally kills Bart, only to reanimate him; Homer wakes up with short-term memory loss; and Lisa, Bart, and Milhouse get super powers from radiation.

Lisa stringe amicizia con una ragazzina appena arrivata in città. Purtroppo, il comportamento prepotente della nuova amica, porta Lisa a prendere una dura decisione.

E' la serata del poker e Homer perde tutto contro Laney Fontaine, una famosa cantante. Nella speranza di riuscire a impietosirla, Homer la invita a cena a casa sua.

Lisa sets out to restore the tarnished reputation of Springfield’s first female inventor. To find her invention, she scours an abandoned asylum and a restaurant that caters to men. Bart joins Lisa at the asylum, stealing one of the homicidal patient’s notebooks, and bragging to the boys at school that he wrote the entries himself. This revelation causes Homer and Marge to believe he is a sociopath, which Bart decides to use to his advantage until things go too far.

Bart’s coming of age story a la “Boyhood” chronicles his life from six years old to his time as an accomplished young man. Along the way, his tense relationship with Homer, an overly uncaring version of himself, and Lisa, who overshadows him in every way possible, shape Bart more than he realizes.

After a photo Marge posts on social media gets Homer fired, he returns to the best job he ever had, a dishwasher at a Greek restaurant. This same post inspires Lisa to code an app that predicts the real-life consequences of anything you post online, only to create sentient artificial intelligence.

There is a new teacher at Springfield Elementary, and a captivated Bart tries everything to win her over. Meanwhile, Homer decides to buy a new brand of “milk,” which causes early puberty, both for Bart (augmenting his wooing powers) and Lisa (whose small bout with acne opens her up to the world of makeup and popularity).

Sanjay passes his stake in the Kwik-E-Mart to his millennial son, Jay, who turns it into a hip, health food market against Apu’s insistence on tradition. Bart, whom Homer had convinced to give up pranking, is called upon to return to his trickster life and take down the new store.

Lonely Professor Frink uses science to turn himself into a man whom women find attractive. Then, overwhelmed by the attention, he invents an algorithm to perfectly pair the lonely men and women of Springfield, realizing that scientific exploration is his true love. Meanwhile, Marge, Bart, and Lisa visit Grampa for Valentine's Day and try to rescue the old folks from a drug-induced hallucination that allows them to relive their happiest memories.

After Bart accidentally sends a sweet homeless woman's cart into the river, he allows her to live in his closet for a small fee. When Lisa discovers that the woman is an incredible folk singer, she offers her own closet and plans a concert, only to be disappointed by Hettie's surprising substance abuse and violent nature. Meanwhile Homer tries to prove he's handy, but accidentally traps the cat in the walls of the house.

After performing CPR on a tased raccoon, Lisa discovers her calling to be veterinarian and becomes an intern at the local office, but learns a tough lesson when her neglected class hamster dies. Meanwhile, Marge moonlights as a crime scene cleaner for a little extra money, and the trauma of the gory scenes make her increasingly dead inside.

Lisa desidera partecipare a una missione per colonizzare Marte. Homer suggerisce a Marge di far finta di assecondare la figlia, ma la sua idea gli si ritorce contro.

After getting into an argument, Marge takes Lisa on a touristy trip to Capital City, where, after attending a musical, they meet the show’s star who reminds Lisa how lucky she is to have such a great mom. Meanwhile, Bart is frustrated that everyone expects his pranks, so he teams up with Maggie to trick people.

Homer recalls a tense family vacation to the Grand Canyon with the Flanders family. At first, the Flanders’ perfection puts the families at odds, but when they get stranded and Ned and Bart go for help, the families finally bond.

"The Simpsons are going to..." Paris (well, Homer and Marge are), but in order to be able to afford the trip, Homer has to smuggle an exotic snake into France so it can be made into a gourmet meal.

After butchering a speech in front of all of his friends at work, Homer turns to improv comedy to gain back his confidence in his public speaking skills. Meanwhile, Marge decides to rebuild Bart’s lackluster treehouse, but tensions rise when Bart questions her building skills. Also, in the episode’s last three minutes, Homer appears LIVE for the first time on television (both for East and West Coast broadcasts) to answer fan questions.

Marge lascia andare Bart da solo al parco, ma poco dopo viene arrestata per aver lascito il figlio senza alcuna supervisione.