Homer heeft problemen met zijn gewicht wanneer hij een superheld mag spelen in een Hollywood-film.

The fourth grade students of Springfield Elementary School decide to spike Ms. Krabappel's coffee in order to teach her a lesson after she takes away their cell phones. She is fired by Principal Skinner, who hires a new teacher named Zachary Vaughn. Although Vaughn is a hip young teacher who impresses the students, Bart is plagued by guilt and tries to get Ms. Krabappel hired back.

De mannen van Springfield zijn in de ban van de gevechtssport. Marge is het beu en wil een einde maken aan de gevaarlijke sport. Nelson helpt haar door een lijst op te stellen met dingen die Marge nodig heeft om haar missie te doen slagen.

Satirische animatieserie, rond het fictieve gezin Simpson, die de Amerikaanse samenleving op de korrel neemt In 'There's No Business Like Moe Business' bedenkt Moe een nieuw, populair drankje dat gemaakt wordt met het bloed van Homer.

Homers leven neemt een drastische wending wanneer hij Carls assistent wordt. Marge is het gesprek van de dag in Springfield wanneer ze poseert voor een sexy kalender.

Skinner vertelt Bart over een voormalige student, die de beste grappenmaker aller tijden was. Marge ontdekt een natuurlijke voedingswinkel.

Cletus laat Homer kennismaken met zijn zelfgemaakte drank, terwijl Lisa drie tienerheksen ontmoet.

Grampa is sitting on a bench waiting for his family when a thoughtful-looking man named Marshall Goldman approaches him and asks to hear about his life. Grampa tells Goldman about the time he was on a World War II battleship, which was hit by an enemy torpedo, and Goldman, a human-interest columnist, publishes it in The Springfield Shopper. Later, Grampa meets Mitch Albom and shares another story with Goldman for a follow-up article. Homer becomes jealous of Grampa's newfound fame and seeks a surrogate father. But when Homer discovers a draft of Goldman's third story, he must race to find Grampa before it is published and his life is changed forever.

Krusty grudgingly adds a pretty, singing cohost named Princess Penelope to his show in order to attract more female viewers. Girls love her, and ratings improve, but Bart and Milhouse want to get the show back to the way it was. The situation gets more complicated when Krusty and Penelope fall in love and decide to get married. Meanwhile, Homer, Lenny, and Carl consider working at a competing nuclear plant when Mr. Burns cuts off their daily doughnut service.

Homer blows off Marge to buy a lottery ticket and winds up winning the million-dollar jackpot. Fearing how Marge will react if she finds out the reason Homer missed their date, Homer keeps his newly inherited fortune a secret and spoils his family with “anonymous” gifts. When Bart finds out, he and Homer spend the money like it’s going out of style, including buying front-row to tickets to see Coldplay in concert.

De Simpsons trekken naar de Olympische Winterspelen in Canada. Homer en Marge doen eraan mee met een curlingteam. Lisa raakt verslaafd aan het verzamelen van Olympische speldjes.

When Miss Hoover asks her students to research their family history, Lisa is horrified to discover that most of her ancestors were bad people – a motley crew of horse thieves and deadbeats. But while rummaging through the attic, Lisa happens upon a diary kept by her ancestor, Eliza Simpson. As Eliza’s story unfolds, Lisa learns that her family was part of the Underground Railroad, a group that helped slaves escape to freedom. Eliza recounts liberating a slave named Virgil, but when Lisa presents her findings at school, some of her classmates refute it, leaving Lisa determined to exonerate her family’s name.

When Bart fails to turn in his homework, Mrs. Krabappel sends a letter home about Bart's behaviour. Despite Bart's best efforts to intercept it, Homer reads the letter, and he and Marge visit Principal Skinner for a parent-teacher conference. Furious, Homer punishes him, but Marge takes a more sympathetic approach. When Bart realizes he can pit Homer and Marge against each other to his benefit, his scheming reaches new heights.

Bart krijgt problemen wanneer hij een meisje van de school kust. Ondertussen stijgt Lisa haar populariteit wanneer ze een slecht cijfer terugkrijgt.

Homer gelooft dat hij de uitverkorene is wanneer Ned Flanders de Simpsons uitnodigt voor een Bijbel-studiereis naar Jeruzalem.

Smithers neemt de leiding over in de kerncentrale wanneer Burns gearresteerd wordt voor kunstdiefstal.

De nieuwe vriendschap tussen Homer en Chief Wiggum wordt op de proef gesteld wanneer Marge vermoedt dat Bart in het drugsmilieu zit.

Homer bouwt een windturbine en Lisa helpt een walvis, die tijdens een storm in Springfield is aangespoeld.

Chief Wiggum installeert beveiligingscamera's in Springfield nadat Homer paniek heeft gezaaid met een bomalarm. Ondertussen verliest Lisa een debat om wille van haar blond haar.

As Mother's Day approaches, Moe narrates an episode in which he writes a letter to Homer, Apu and Reverend Lovejoy, who are vacationing with their children, and threatens to run away with one of their wives. While the trio tries to determine whose wife Moe is referring to, Homer, Lovejoy and Apu flashback to the intimate moments they initially ignored between Moe and Marge, Manjula and Helen Lovejoy. But when the boys return from their trip, they're in for the surprise of their lives.

Bart becomes convinced that his new neighbor, Walt, is his archenemy, Sideshow Bob, disguised and back for revenge. But when Marge tries to convince Bart otherwise by taking him to visit the state penitentiary, a disturbing truth is revealed.

When Moe discovers a hidden talent for judging contests, he is approached by a television agent to join the AMERICAN IDOL judges' panel. Moe flies to Los Angeles where he tours the Fox lot and receives some sage career advice. Meanwhile, Homer drives Marge crazy when he begins hanging around the house.