When Bart commits an extremely destructive prank, he is given Focusyn, a pill to help him concentrate in school. At first the results are impressive, and then Bart starts believing in a conspiracy involving spy satellites and major league baseball.

In "I Know What You Diddily-Iddly-Did" the Simpsons fear they have killed Ned Flanders. "Desperately Xeeking Xena" satirizes superheroes of yore with "Stretch Dude" Bart and "Clobber Girl" Lisa. And "Life's A Glitch, Then You Die" depicts the upcoming horror of Y2K.

When Marge leaves the house to recuperate from a skating injury, everything goes to hell - until Lisa convinces Homer and Bart they have leprosy.

Ned's wife Maude is inadvertently killed by a T-shirt accident at an auto race. Homer and his family try to help Ned cope.

While making funeral arrangements for Grampa's future, the funeral planner pitches the idea of a mausoleum that uses the same amount of cement as a full-sized tennis court. This prompts Homer to instead build a tennis court in his backyard, initially mistaking the sport for "Foxy Boxing". The tennis court makes Marge and Homer popular in town, but it turns out that this is only because Homer's inferior tennis ability makes them an easy target. Bart on the other hand, shines as a natural.

Homer's rush to the hospital to reattach his thumb, Lisa's rush to school to win the science fair, and Bart's run-in with an illegal fireworks scheme are interconnected in a parody of Go and Run Lola Run.

After finding a sketchbook belonging to his late wife Maude, Ned Flanders opens a Bible-themed amusement park to honor her memory.

Homer develops a snoring problem, so Marge decides to spend a night with her sisters Patty and Selma. After a night of drinking, Marge sees a news report about her ex-prom date Artie Ziff, who is now very wealthy, and decides to send him an e-mail. Artie is still obsessed with Marge, so he offers the Simpsons $1 million in exchange for Marge spending a weekend with him.

Lisa tries to fit in with two college students by lying about her age. She finds that the college atmosphere is perfect for her, but her lie is soon discovered and she is shunned by her fellow elementary school students. Meanwhile, Bart is diagnosed with a weakened immune system after getting bitten by a Chinese mosquito and must live in a plastic, germ-free bubble.

Thinking Homer does not find her attractive anymore, Marge decides to get liposuction, but instead receives breast implants. She becomes adored by many of the men in Springfield, and becomes a spokesmodel for trade shows. Meanwhile, Bart and Milhouse try to imitate a stunt they saw on an episode of Batman that guest stars Krusty the Clown. When the stunt ends badly, media watchdog groups blame Krusty, forcing the clown to make his show more safety-conscious and less fun.