When Marge leaves the house to recuperate from a skating injury, everything goes to hell - until Lisa convinces Homer and Bart they have leprosy.

This year's Halloween story sees The Simpsons as "The Munsters" (with everyone except Lisa getting killed), Homer as a wandering spirit on the hunt for a good deed in "G-G-Ghost D-D-Dad," Bart and Lisa as peasants in a fairy tale forest in "Scary Tales Can Come True," and Lisa inadvertently dooming mankind by rescuing a dolphin in "Night of the Dolphin."

Homer and Bart become father–son con artists (after Bart is given money out of pity when Homer decided to not take him home), but soon find that they are the ones being had.

In the twelfth Treehouse of Horror episode:

Hex and the City – While on a day trip through Ethnictown, Homer's bumbling catches the ire of a gypsy, who curses Homer's family and friends into receiving nothing but bad luck.

House of Whacks – in this mixed parody of Demon Seed and 2001: A Space Odyssey, Marge buys an automated house and customizes it with the Pierce Brosnan personality, who falls for Marge and attempts to murder Homer.

Wiz Kids – In this Harry Potter parody, Bart and Lisa go to a school for wizards, and Lord Montemort (Mr. Burns) uses Bart to capture Lisa's magic.

Guest star: Pierce Brosnan and Matthew Perry.[20]

Springfield is officially declared the World's Fattest Town after an attempt to break a world record lands everyone on top of a truck scale. Out of embarrassment and disgust, Marge goes on a crusade against the local sugar corporation. However, when sugar is banned, Homer, Bart, Mr. Burns and Apu start bootlegging sugar.

Marge gets mugged and becomes so traumatized that she develops Agoraphobia. She hides in the basement. Having little else to do, she decides to exercise with a weight set Homer bought from Rainier Wolfcastle's garage sale. She becomes so strong and confident that she is able to leave the basement. She continues working out and decides to start taking steroids so she can enter a bodybuilding competition. One night at Moe's Tavern she loses her temper and starts destroying the bar and fighting all of the patrons. Homer confronts Marge and says he misses the sweet woman that he married. Marge, horrified at what she has done, apologizes and decides to stop working out.

When Maggie does better than Lisa on an IQ test, Lisa becomes upset over no longer being the smart one and tries to lead Maggie astray.

Lisa agrees to enter a Krusty-sponsored "Li'l Starmaker" competition and panics when another contestant (guest voice Fantasia Barrino) outperforms her.

Homer is fired and decides to buy an ice-cream truck. Marge makes use of the mountains of Popsicle sticks from Homer's ice-cream consumption by creating sculptures of Springfield citizens with them, leading to a feature about her on the news.

A freak accident gives Homer an operatic singing voice, and he becomes a star at the Springfield Opera. But with fame and fortune comes a price: He's continually bothered by fans, an obsessed woman in particular.

Homer cheats on his diet, so Marge gets a reality show called "The Sneakers" to check up on him. Meanwhile, Bart and Lisa fear that a prank they played on Martin Prince had deadly consequences.

The men and boys in Springfield become obsessed with Ultimate Punch Kick and Choke Championships, a violent sport where fighters inflict severe pain on each other. When Marge and her friends stage a protest against the sport, the show's promoter embraces the controversy and challenges Marge to a match, promising to shut down the competition if she wins. She begins to train with rhythmic gymnastics, but her family step in and get her professional martial arts help to give her a real chance at winning.

Homer is completing his court-ordered community service when he befriends his supervisor, Chief Wiggum, by offering him one of his sandwiches. Touched by the act of kindness, Wiggum assigns the other convicts unpleasant tasks, but allows Homer to join him at the picnic table. They continue to grow close, but when the Chief gets injured during a botched bank robbery, Homer doesn't come through when Wiggum needs him the most. Meanwhile, Bart becomes addicted to Battle Ball, a Japanese game made up of plastic balls and magnetic cards, and his family and teachers try to help him kick the habit.

Simpsons' twentysecond Halloween show.

The Diving Bell and the Butterball:

Homer is bitten by a radioactive spider.

Dial "D" for Diddly:

Ned becomes a serial killer.

In the Na'Vi:

Bart and Milhouse in an Avatar spoof.

Grampa has to move into the Simpsons house following a fire at the retirement home, and on moving day, Homer 'throws his back out' and 'rests' at home. He later finds an advert for a video game, Villageville on his myPad, and starts playing. During that time, Homer loses Santa's Little Helper. When the family find him, Homer doesn't seem to care because he's "not a dog person". Grampa later tells the rest of the family the story of Homer's childhood companion, pet dog Bongo.

Lisa dates a competitive eater; Bart benefits from helping convict Snake Jailbird escape from a jam.

Bart schemes to bring down his new teacher, Mr. Lassen, who is a terrible bully. Meanwhile, The Simpsons go to Burning Man.

When Lisa becomes scared at the Krustyland Halloween Horror Night, Homer is forced to take down his Everscream Terrors decorations. Halloween pop-up employees seek vengeance on Homer for causing them to lose their jobs, and rob his house while Homer and Lisa hide out in the attic. Homer and Lisa light up their stored holiday decorations to attract attention and stand up to the intruders.

After Bart accidentally sends a sweet homeless woman's cart into the river, he allows her to live in his closet for a small fee. When Lisa discovers that the woman is an incredible folk singer, she offers her own closet and plans a concert, only to be disappointed by Hettie's surprising substance abuse and violent nature. Meanwhile Homer tries to prove he's handy, but accidentally traps the cat in the walls of the house.

Bart gets in trouble on Grandparents Day at school and is forced to hang out with Skinner's mother as punishment. After spending time with various grandmas in the neighborhood, he learns the benefits of hanging out with the elderly, but eventually recognizes the dangers of taking advantage of them. Meanwhile, Peekimon Get has taken over the town of Springfield.

Marge wants a job, and stumbles into becoming a plastic food storage container-selling drag queen. Meanwhile, Lisa tries to make the world better in the style of "Amelie"

When Maggie goes to preschool, Marge decides to get a job to pass the time and ends up working at an upscale weed dispensary; Homer decides to open his own dispensary that mimics a sketchy drug deal, putting their two businesses at odds.

Santa's Little Helper nips at Marge, causing the family to reflect on the difficult life that the dog led prior to being adopted by the family. They end up reuniting him with his mother to avoid having to euthanize him.

A British secret agent comes to Springfield in search of a Russian spy.

Bart can't control his feelings when he gets a new teacher. Meanwhile, Lisa befriends an octopus.

In a book-themed trilogy, Marge's resentment takes monstrous form, Lisa tries to save the planet through murder and Homer learns he's not the man he thought he was.

Marge feels an overwhelming dread of the empty nest.