Dr. Kelso's beautiful but unethical replacement, Dr. Maddox, shakes things up at Sacred Heart, while J.D. struggles to manage a new crop of incompetent interns and Carla helps Elliott put her ego in check.

J.D. and Turk make a huge sacrifice concerning a decade-long steak night tradition for a dying patient. Meanwhile, Dr. Maddox, the new Chief of Medicine, begins to show her true colors.

Dr. Kelso and Dr. Cox have to work together again to get rid of Dr. Maddox, while Carla faces an incompetent intern.

Featuring a special appearance from Sesame Workshop's "Muppets", J.D. learns a lesson about the gift of compassion, while Elliot gets scammed by intern Katie to secure a spot on Turk's team.

As his increasing workload from being Chief of Medicine begins to take a toll, the unimaginable happens when Dr. Cox reaches out to Dr. Kelso for friendship.

J.D. and Turk gather up a new crop of interns as they organize their annual (and historically unfunny) sketch show.

J.D.'s ego becomes inflated after Dr. Cox finally gives him the recognition he's been waiting for. Elsewhere, the senior staff receives insight from the interns.

A combination of a full moon and some bad luck causes Sacred Heart's new crop of interns to receive their toughest case load yet while Elliot makes an important decision regarding her future as a doctor.