J.D. begins to feel distant from Turk, when he leaves him abandoned every time that he tries to talk to him. Elliot fights with Kelso for calling her "sweetheart," and she seeks Dr. Cox's advice. J.D.'s relationship with Elliot goes in a time race, when he has 48 hours to kiss her before he is put into her "Friend Zone."

J.D. is frustrated when his budding romance with an ex-patient wilts as their dates are constantly interrupted by emergency calls, while the beastly Dr. Kelso becomes less fearsome to the wide-eyed interns, when Dr. Cox informs them how to avoid the blowhard's bite. In addition, a perplexed Carla and Turk deal with their first sexual intimacy complication.

J.D. fears being contaminated with Hepatitis B, after a needle accidentally sticks his forearm.

Meanwhile, Elliot has a hard time combining her new relationship and keeping up with studies. Turk obsesses about getting in shape, after Carla makes a fat joke about him.