Cindy O'Malley, a friend of Jake's, is witness to a murder, but is spotted by the killer and he chases her and shoots her. McCabe & Co has to take care of her baby while they try to find her and the killer.

A psychiatrist is having an affair with a patient and her husband finds out and wants a divorce. So she manipulates her lover into killing him.

Neely and Jake investigates a case where dead bodies are found with their livers surgically removed.

A doctor is murdered, and is discovered to have been making child pornography. The prime suspect is Elliot Edwards, a city council member with a spotless record.