Ryōta Sakamoto is ranked #10 worldwide in Btooom!, an online game where players kill each other with bombs. After a game one day, he mysteriously awakes in a real life version of the game.

A typical high school girl, betrayed by her neighbors, a forced player in the game of Btooom!, betrayed by the group she teamed up with. All men are scum.

While chasing after the mysterious girl, Ryota runs into Taira Kiyoshi who helps fill in the blanks in his memory.

Kira Kosuke is a disturbed child, but when on the island his true nature can finally come out, unchecked. That is until he faces the best Btooom! player in Japan.

A pantless corpse floats by Taira and Sakamoto while they are eating lunch. When Sakamoto leaves to investigate he finds a gruesome scene and a familiar figure.

In the moment of danger, trust issues start to show between Taira and Sakamoto. Sakamoto wants to save everyone especially the girl who just tried to kill him.

Miyamoto, the mercenary, has found Sakamoto and his team. This dangerous player will do anything it takes to win.

As Sakamoto and Himiko try to rest for the night, Himiko wrestles with the idea of telling Sakamoto her true identity, but before she can do anything she is visited by a “ghost”.

A new player has joined Sakamoto's team, but he carries a dark secret. Before the team could dive deeper into the new players past, a food drop overhead brings many players out of hiding.

It seems the players on the island are interconnected in more ways than one. While Sakamoto mulls over this new information, the good doctor begins his end game.

With Ryouta out of the way, Himiko will be an easy target for Date, but Shiki has other plans for the doctor.