On their way to Pago Pago for a musical stint, Josie and her companions find themselves in troubled waters when the ship on which they are sailing is torpedoed by Captain Nemo.

Over the Amazon, the companions become part of a cargo drop on Dr. Greenthumb's supply zone. Greenthumb brings the group to his plantation where he sends them for a walk along his deadly garden path.

After checking in at the Bombay Tilton Hotel, Alan, Josie and Alexandra are kidnapped by Kaseem, a political usurper who leads a band of hooded scalawags called the Secret Six, and taken to his sanctuary.

The Pussycats search for the Evil Eye, a mysterious figure with hypnotic powers, who has kidnapped Valerie and an Arabian princess.

A skiing vacation in the Alps accidentally leads the gang to the mountain fortress of Midas, a gold hoarder who has invented a gold-destroying blue microbe mist with which he is seeking to dissolve the world's supply of gold.

The Pussycats befriend Professor Isaac Belfour, a scientist who invented an invisibility formula. They take him along for their gig in Puddletown, England, to protect him from Mr. X, a former laboratory assistant who stole the formula.

The Pussycats are involved in an atomic chase in Mexico when they are pursued by The Scorpion, a power-hungry ringleader who is after a vial of glowing nuclear capsules hidden in the hollow of Melody's drum.

The group stumbles on an impossible mission in Amsterdam when Melody, mistaken for a secret agent, is given a pair of wooden shoes concealing a miniature tape recorder and picture.

The Pussycats are chased by a tyrannosaurus after a plane taking them to Puerto Rico makes an emergency landing in a forest.

The Pussycats are doomed for stardom when the dirigible in which they are performing at the World Expo in Florida takes off and lands on the island of Dr. Strangemoon, a scientist who plans to launch satellites that will attract comets.

The Pussycats become the target of an inscrutable Chinese man known as the Serpent when Melody acquires an ancient Chinese coin that holds the secret to great power.

Melody becomes a brain-child when Prof. Leighton, a renowned scientist, transfers a secret formula recorded on computer tapes to her brain.

The Pussycats and their companions become jet-setters when they travel the globe in one day during a frantic chase. The Shadow, leader of a secret international crime organization, is after a black box handed to them by an Interpol agent.

The Pussycats accidentally get their paws on a top secret blueprint intended for the World Scientific Foundation and are returning the material to the Foundation when intercepted by The Lazer.

Josie and the Pussycats nearly get early retirement when they board an empty yacht controlled by a designing countess who seeks to prematurely age the girls.