Mindy makes an unfortunate first impression on her fellowship class at Stanford; the doctors at the practice are determined to win a basketball tournament.

A run-in with an ex-boyfriend has Mindy questioning her relationship with Danny; Morgan and Danny think they see Lauren cheating on Jeremy with Peter.

Rob (guest star Tate Ellington) gives Mindy an opportunity to start up her own practice in San Francisco, and she struggles to tell Danny, especially when Danny shows her the brownstone he bought for the two of them in New York! Meanwhile, Jeremy and Peter grapple with the fact that Lauren is moving to Texas and leaving them both behind.

Mindy has made up her mind to move to San Francisco and start a practice with Rob, but her credit history jeopardizes their ability to get a loan. Meanwhile, Danny tries to let the office know that he is moving to San Francisco with Mindy, but they're convinced his "big news" is something completely different.