Severide is getting impatient with the police as Vince Keeler walks free. Meanwhile, the house pulls out all the stops to save a girl trapped inside a donation bin, Mouch learns that Boden’s secretary Connie is not someone to mess with and the squad and truck are called to a serious high rise fire inside a 20-story downtown office building.

A house fire sees the team attempting to save the lives of a couple trapped inside. Chief Boden prepares to start his new family. The combination of life at work and home sees Casey and Dawson drifting apart.

Boden's new neighbor asks him for a favor that could have serious repercussions. Severide is upset when he's treated like a candidate by Patterson. Cruz is visited by a gangbanger who knows his brother. The team responds to a call that involves an 18-wheeler; and is thanked with tickets to see Rush.

When similar car accidents uncover the fact that someone may be targeting innocent people, a determined Dawson takes matters into her own hands to help push things along. Severide does everything he can to make Anna feel welcome in her new Chicago surroundings. Herrmann, Kidd and Dawson decide to have Molly's included as a stop in this year's pub crawl. Meanwhile, Casey tends to his Alderman's duties when a persistent constituent asks for his help in resolving an issue.