An arsonist targets Lt. Severide. Meanwhile, Station 51 is under scrutiny by Gail McLeod, a financial consultant for the city who is deciding if any firehouses should be closed. Mouch receives a visit from his Japanese girlfriend, Lt. Casey "celebrates the one-year anniversary of Andy's death, and Shay suspects Severide's paternity.

In the wake of Heather's incident, Lt. Casey is having a hard time handling his newfound responsibilities. Lt. Severide is on edge dreading the next attack from the firehouse's arsonist. Meanwhile, with Renee back from her mother's, Severide knows he has to confront her about his paternity suspicions. Elsewhere, Mouch begins his campaign for union president and Shay and Dawson feel that they need to get out more.

Lt. Severide has his strong ideas on who the serial arsonist is, but first needs to find proof to back up his suspicions. Meanwhile, Lt. Casey adjusts to his new lifestyle in the wake of recent events and Molly's bar is failing, much to the dismay of owners Hermann, Dawson and Otis. Elsewhere, Dawson goes out on a date with Jay Halstead, one of the bar regulars, and Mouch's campaign trail starts to get on track with the aid of Isabella, an old friend of Dawson's.

Lieutenant Severide is anxious to implicate the serial arsonist, while Dawson and Shay get a shock on a routine call. Meanwhile, suspicions continue to point to Clarke as the mole inside the firehouse and Molly's falls deeper into the red. Elsewhere, Mouch campaigns for union president, with the aid of Isabella, and Boden butts heads with Gail McLeod.

Boden's future with Firehouse 51 is on the line and McLeod keeps on him about his past wrongdoings, pushing him toward an early retirement. With Boden considering his options, McLeod calls on an unlikely candidate to potentially replace him as Chief. Meanwhile, it becomes clearer who the mole inside the firehouse is and everyone takes measures to make their disdain for him known. Meanwhile, Shay's social life is in full bloom and Arthur continues to take money from the struggling Molly's.

While out on a jog, Severide comes across a secluded and empty construction site and encounters a young boy who has been trapped in a backhoe loader and is in dire need of assistance. Boden and McLeod continue to butt heads about the future of the firehouse and Boden breaks news about his future to Casey. Meanwhile, it's election day for the union presidency and Mouch and Greg Sullivan have a debate on Otis' podcast. With rival bar Game Day's future in peril, the finger is being pointed at Molly's.

Lt. Casey returns to work at Firehouse 51 after nearly being killed in a building collapse and Shay meets Allison Rafferty, her new partner, who is friendly to everyone except her. Dawson begins her rigorous training at the Chicago Fire Academy, while Lt. Severide prepares for his stint as instructor. Meanwhile, Clarke stubbornly does not speak with the police about the murder in which he is the prime suspect and the future of Molly’s looks bleaker than ever.

Lt. Casey and Dawson volunteer to help at a charity run at Chicago Medical when a massive explosion sends Chicago into chaos. With one of their own missing in the blast, the firehouse is tested like never before.

The crossover continues on Chicago P.D. S01E12 8:30 PM (II)

The Chicago fire team works seamlessly with Chicago Med personnel to help aid victims of a deadly gas leak, but things quickly take a turn for the worse when the hospital is suddenly forced into quarantine.

The team is on high alert when a previous incident during a fire call leaves a dangerous man on the loose with a vendetta to target Lt. Casey and Firehouse 51, and prompts CPD to step in. Dennis Mack, a buddy firefighter of Severide's father, comes to town to shadow the squad but may have ulterior motives. Meanwhile, Brett and Antonio's relationship hits some bumps in the road when his ex-wife Laura surfaces and Casey has a present for Dawson.

While working to track down a bombing suspect, Voight and Antonio meet with Chief Boden, who unwillingly agrees to let Dawson and Brett go undercover. As the investigation continues, Boden, Casey and Severide lend their skilled expertise in the investigation. Elsewhere, Kidd and Zach's relationship hits a bump and Cruz has a hard time expressing his true feelings for Brett. Meanwhile, Herrmann and Connie are forced to come up with an alternative solution when two birthday parties are booked on the same day at the firehouse.

The crossover starts on Chicago Fire S05E016 Profiles (I).

Firehouse 51 is faced with a daunting challenge when an out-of-control blaze consumes a 15-story apartment complex, trapping victims on the top floors. Complicating the rapidly escalating situation, members soon discover that someone close to home may be one of the trapped victims.

The crossover continues on Chicago Med S04E02 When to Let Go (II) and Chicago P.D. S06E02 Endings (III).

A spate of robberies comes to light after a firehouse lockbox key goes missing; Sergeant Hank Voight suspects a firefighter may be involved, and with Boden's support, he recruits Cruz to go undercover to help sniff out any suspicious activity.

The crossover continues on Chicago P.D. S06E15 Good Men (II).

Severide gets angry at Cruz when he feels his orders were disobeyed in the field. Boden reconnects with an old high school friend during a call to a house fire. Herrmann has issues when one of his favorite knick-knacks from Molly's goes missing.

A rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago’s finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening.

The crossover continues on Chicago Med S05E04 Infection, Part II (II) and Chicago P.D. S07S04 Infection, Part III (III).

Kidd must prove herself at the National Firefighter Leadership Conference while the rest of Firehouse 51 is called to two eerily similar car wrecks. Mouch tries to keep everyone in the firehouse informed by starting a newsletter, but things quickly get out of hand. Cruz deals with a heartbreak.