The Chicago fire team works seamlessly with Chicago Med personnel to help aid victims of a deadly gas leak, but things quickly take a turn for the worse when the hospital is suddenly forced into quarantine.

Casey is placed in a dangerous situation while working undercover to bring down a trafficking ring being run out of Nesbitt's club. The squad's high turnover rate results in an unwelcome surprise for Severide. Dawson recognizes that her life is about to change. A new candidate makes an unusual first impression. Residents band together to protest a drug den in their neighborhood.

Evidence that seems to exonerate Boden may not be enough. Brett and Chili find themselves in a precarious situation. The team responds to a stuck elevator in a hotel. Jimmy Borrelli's older brother wants him transferred to a different house.

The squad members come together to support one of their own. Herrmann tries to figure out how to reopen Molly's after it gets shut down. Severide digs deep into the arson investigation.

Boden offers to host a wedding at the firehouse after a fire destroys the original location, but it doesn't sit well with Chief Riddle, who also butts heads with Dawson over her ability to perform. Severide fights for his old position. Capt. Patterson finds himself torn between leadership and his colleagues.

Herrmann fights for his life after being stabbed; Cruz hits the streets to find Freddie. Mouch proposes to Trudy.

The crossover continues on Chicago Med S01E05 Malignant (II) and Chicago P.D. S03E10 Now I'm God (III).

Severide and Cruz find a child's remains inside a chimney while investigating a possible carbon monoxide leak inside a home. In other events, Casey braces for the worst in his run for alderman while Alderman Becks continues to bad mouth him to the press.

Casey steps up to help a teenager being bullied by a gang; Severide bonds with a detective’s son after her life is threatened; and Kidd and Herrmann go head-to-head in a test of bar knowledge.

Firehouse 51 unites to help a young boy in tragic circumstances. A high-powered political consultant helps Casey navigate a potential scandal. Cruz makes a mistake that nearly costs him his life.

Dawson saves a young boy from an apartment fire. Kidd's idea for Molly's doesn't go as hoped. Severide hits a wall while advocating for new fire masks. Cruz and Brett utilize a secret weapon to get Otis to see Dr. Halstead take a blood test.

Casey and Dawson find themselves in the midst a potential political mess. Stella has to make a big decision about her ex-beau. The squad responds to an auto accident. Severide befriends a socialite. Brett and Mouch set aside their writing differences for the greater good.

Truck and squad are called to aid in a massive all-city response when an old, ill-equipped factory-turned live/work space quickly turns into a firestorm, trapping countless unsuspecting victims. The dire situation quickly turns personal when it is discovered that one of Chicago PD's own has a family member at the scene.

The crossover continues on Chicago P.D. S04E016 Emotional Proximity (II) and Chicago Justice S01E01 Fake (III).

After responding to a car accident, Casey and Dawson become skeptical when a domineering husband continues to answer for his injured wife. Cruz becomes frustrated with Herrmann and Mouch when he discovers they have contacted people regarding his "Slamigan" invention without his knowledge. Kidd uncovers something meaningful and important to Severide while Brett discovers some potentially unsettling news.

Firehouse 51 is faced with a daunting challenge when an out-of-control blaze consumes a 15-story apartment complex, trapping victims on the top floors. Complicating the rapidly escalating situation, members soon discover that someone close to home may be one of the trapped victims.

The crossover continues on Chicago Med S04E02 When to Let Go (II) and Chicago P.D. S06E02 Endings (III).

A rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago’s finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening.

The crossover continues on Chicago Med S05E04 Infection, Part II (II) and Chicago P.D. S07S04 Infection, Part III (III).

A series of mysterious gas leaks has members of Firehouse 51 puzzled and spread thin. Brett’s conflicted when her birth mother gets serious about tracking her down. Severide misunderstands his role as Cruz’s best man. Mouch bites off more than he can chew.

Tension builds when a group of rabble-rousers attempt to lock down the firehouse. Brett is faced with a monumental decision. Cruz readies himself for a big day. Gallo and Ritter attempt to launch Firehouse 51 into the social media age.

When one of 51's own gets injured on a call, Lt. Severide becomes obsessed with helping out. Foster contemplates a big decision. Kidd is concerned for one of her high school trainees.

A series of suspicious fires sends 51 on a search for the cause. Casey continues down a troubling path. Mouch is looking to make his long-awaited dream come true.

A new recruit with ties to the CFD tests Serveride's patience. Violet receives a mysterious note that sends her and Brett on a hunt for the person who wrote it.

Mouch builds a classic firetruck model for the Deputy District Chief but needs some assistance from Gallo and Ritter. Brett and Violet encounter multiple victims with a strange set of symptoms. Cindy's chemotherapy results loom over the Herrmann family.