碟中谍小组这次的对手是一个职业杀手，他会在最后一刻随机做出决定，以确保他的行动不可预测。他们必须为各种可能的情况做好准备，以接近杀手，挫败他的计划。

梅尔·布莱肯是西海岸最大的非法毒品经销商之一。制药巨头卡梅隆合法地将毒品卖给墨西哥的一个中间商，然后走私到洛杉矶的布莱肯。为了揭露这一行动，碟中谍小组迫使卡梅隆在美国本土直接与布莱肯交易。

巴尼被一种化学药剂麻痹并被抓获，这促使菲尔普斯想出了营救巴尼的计划。然而，碟中谍小组需要一个在计算机方面拥有巴尼专长的人。所以他们才请了杰罗姆·卡林博士。可惜卡林博士不打算合作，这使得任务更加困难。

菲尔普斯回到家乡处理一些家族生意，并与儿时的朋友团聚。不幸的是，这种快乐的时刻是短暂的，因为他童年朋友圈的几个女人都被谋杀了。吉姆最终决定叫来碟中谍小组成员帮助他调查。

碟中谍小组必须挫败由总统暗杀引发的政变企图，他们抓住了政变领导人，并使用了一个精心策划的计策来说服他揭露杀手。

在前往瑞士与碟中谍小组会合的途中，帕里斯被一队敌方特工抓获，被洗脑，并被设定为杀死他的上司-菲尔普斯，成员们必须弄清楚他们的同事究竟发生了什么，以挽救他的生涯和生命。

碟中谍必须证明一名美国商人的清白，这名商人被诬陷谋杀了他的妻子。成员们伪装成各种各样的日本艺术大师，诱使真正的杀手招供。

亚历克西和安娜·克尔科斯卡兄妹想叛变，并向美国提供一份支持西方的政府官员名单。但这其实是亚历克西和警察局长彼得罗维奇设下的一个陷阱，他们希望一举得到这份名单并让西方国家难堪。尽管有陷阱，碟中谍小组必须救出安娜并夺回名单。

一个想当间谍的人在东欧国家碰巧遇到了碟中谍小组的一次行动。当这个外行成为超级侦探的梦想变成贪婪的时候，碟中谍小组巧妙地操纵他和政府安全部队来完成他们的任务和逃跑。

在一个白人统治的非洲国家，一次完美的解救任务因为一名审讯者的突然到来而发生了意外。在逃跑中巴尼受了伤，但他得到了一位善良女子的帮助，他们对彼此的好感越发强烈。而与此同时，其他成员正在寻找失踪的巴尼，帕里斯扮演了一个诱饵的角色。

Albert Zembra, head of the Mediterranean branch of the Syndicate, is dying of cancer and plans on passing his list of opium farms to his chosen successor. He plans on turning power over to Carlos Empori, engaged to his granddaughter. Paris poses as a mobster and old friend of Eve's and ""renews"" his friendship with her, while Phelps, as Zembra's rival, warns Carlos that Paris plans to take over. Barney stages a fake assassination on Zembra, thwarting Carlos' security and making him look incompetent, then Paris and Paris-as-Zembra stage a conversation to make Carlos believe Zembra will give power to Paris. Carlos helps Jim kidnap Eve, but the plan goes awry when Eve reveals she knows Paris is a fake. Paris puts his life on the line by counting on her silence to complete the plot. Eve stays silent, Carlos is set up as a traitor to Zembra, and the dying mobster turns the information over to Paris.

After completing a mission Paris is undercover as an American businessman and still in disguise when he is kidnapped by Latin American revolutionaries led by terrorist Robert Siomney - they ask for the release of three prisoners in return for Paris' life. Paris fakes a disease forcing the government to drop medication, which the IMF has planted a tracking device in. Once they know where the revolutionaries' compound is, Jim fakes the exceution of two of the prisoners, putting pressure on the revolutionary leader Jorge Cabal since his son Luis is the third prisoner. Dana poses as Luis' girlfriend to get close to Jorge so Siomney orders her covert death to keep Jorge on track - Barney takes the killer's place and rescues Dana. Then Jim fakes Luis' death as well - Barney fake-kills Paris and then they reveal that Luis got a last-minute reprieve. With nothing else to bargain with, Jorge turns over Siomney, Barney in disguise, and the ""dead"" Paris in return for the government commuting his

Phelps must stop Charles Peck from using violence, created by professional provocateur Billy Walsh, to elevate his puppet, Mayor Steven Tallman to the governorship. Dana is a provocateur herself, arrested by Barney the current governor's representative. Walsh gets Dana out, and Paris is a blackmailer who convinces Tallman that Dana is his previously-unknown illegitimate daughter. Peck is concerned that Tallman (actually Paris in disguise) will confess their plans to save his ""daughter"", and orders Walsh to kill Barney and Dana. Barney stops Walsh on TV before he can blow up a crowd of demonstrators and police during a protest, and Paris-as-Tallman confesses to Peck's involvement.

Larry Collier, newspaper editor and Barney's brother, is killed while trying to establish a link between corrupt police chief Abbott and Corley, the head of a ghetto mob who masks his illegal activities with an insurance front company. Barney, set up with a past as a crooked accountant, gets close to Corley by rescuing is secretary Millie - Corley hires him on when he finds out about his ""past."" Barney plants money to make it look like Corley's assistant Goslin is working against him, while the IMF use a phony seance to convince Goslin to quit with some incriminating evidence. Jim arrests Goslin with the evidence, a codebook, and uses it to force Abbott to back him as a mob boss then bribes Corley's guard to try and kill the mob leader. Barney rescues him and Corley runs into Jim, who threatens to take him to Abbott - knowing Abbott will have him killed, Corley turns state's evidence.

James Read, an enemy agent, is posing as an analyst to get to a top-secret U.S. missile guidance system being tested and steal the plans - the IMF must have him take back fake plans and unwittingly pass on the incorrect information to his superiors. Dana takes the place of Read's contact and he and fake boss Jim fake a romantic relationship so Read can get blackmail photos and use them to turn over the system. Read tells Dana of his plan to kill Jim, but before she can warn Jim, Dana is kidnapped by Hecker, a psychopath who believes Dana is a former girlfriend he killed. After Willy saves Barney from a firetrap meant for Jim, Paris and Barney manage to rescue Dana and alert Jim just in time to avoid a rigged car, convincing Read he's in the clear with the guidance system.

An enemy power has launched a satellite containing a thermonuclear bomb and the IMF must destroy it. The control center on an island in the Adriatic Sea is surrounded by an impenetrable minefield designed by an American defector, Norris. Barney secretly sets off some of the mines - without an explanation, the facility security call in Norris, whom they haven't seen. Paris takes Norris' place and using plans that Jim stole earlier, shuts down part of the field, and Barney gets in to program the system to drop the satellite out of orbit. Unfortunately, on the mainland the real Norris kills his girlfriend, a government spy, and Paris-as-Norris is arrested for the murder! This also leaves Barney trapped in the middle of the minefield. Jim and Doug manage to extract a confession and the location of the murder weapon from Norris before Inspector Koder (who knows the real Norris) can spot Paris. Dana comes in and manages to covertly slip Paris the information they've set up to make it look li

Gregory Tolan leads an underground cell specializing in bank robberies with the money going to finance an American revolution. His mysterious sponsor is Jonathan Brace, who runs other such cells throughout the U.S. The IMF must find out Brace's identity and apprehend him. Phelps (as a demo expert) and Dana (as his insider at Tolan's next target) get recruited and has to make sure Tolan steals the money without the police knowing so he can lead them to Brace. When Jim stops Tolan from shooting Willy (disguised as a clerk), the police are alerted and Tolan's team takes refuge. Jim goes to get a (bugged) car since Brace won't come to them, Paris and IMF guest agent Grace play the homeowners, and Dana and Tolan exit with the money when Brace orders them to. Jim stops the hostages from getting killed and they follow Tolan to Brace and bring them both in.

In San Pascal Premier Miguel Fuego and his nephew Ramone have signed a secret arms treaty with a Communist power to permit nuclear weapons aimed at the U.S. into their country. The IMF must expose the treaty before the missiles are installed. The team has Paris claim that Ramone's late father was killed by Miguel and that Paris' father at the closed Madrena Prison can verify this. The IMF secretly reopen Madrena prison and have Ramone arrested for fake-killing Doug, and Paris plays his previous character's father, who claims a diary will prove his claim. Ramone escapes and rejoins the younger Paris' character, who makes him believe the diary is on his father Victorio's body, lying in state. Barney and Doug have secreted replaced the body with a wax dummy behind the backs of the guards and planted a diary ""proving"" Miguel had Victorio lobotomized. Upon recovering it, Ramone goes to an asylum where a braindead ""Victorio"" is being kept. Enraged, Ramone takes Paris to the safe containing t

John Darcy, codename 'Kitara', leads a liberation movement in the African country of Bocamo and has been inadvertently captured by the ruthless Colonel Kohler. Kohler plans to torture Kitara, who if he confesses his true identity will result in the destruction of the entire movement. Kohler is after a truckful of government gold bullion Kitara stole. Jim and Doug play agents while Barney is captured and gets the location of the bullion from Kitara and gets it to Jim. Doug warns Kohler about ""lamposa hycondra"", a disease that causes blacks to turn white. After Kohler takes a IMF-rigged shower he wakes up the next morning to find himself black! Dana as a reporter introduces Kohler to shopkeeper Paris, who has ""proof"" that Kohler's grandfather was black. Kohler goes on the run and Paris hides him out at the gold's location. The authorities find Kohler there and believe he is Kitara and have him arrested, then hand the gold over to Jim to deliver it to headquarters.

Howard Bainbridge, a chemical warfare expert who defected to East, was contaminated by his own experiments and then returned back to the U.S. and his family manor, where his father (a paranoid arch-conservative) had him killed and the body buried. Since Howard destroyed the records before defecting, the IMF must recover the body to get a sample of the chemicals. The elder Bainbridge, Justin, is unaware that his head of security is an enemy agent also trying to find Howard' sbody. The IMF gain access to a air-raid shelter on the grounds and start ""haunting"" Justin with a secretly-implanted microphone and holographic projectors. Plagued by visions only he can see of his son and his dead wife Janette (played by Dana), Justin calls in physician Paris, who recommends he assauge his guilt conscience and Justin ends up digging up his son's body, which the IMF take.

Alexander Vanin, arrested and convicted for espionage, hid a list of agents operating in the U.S. His control, Mishenko of the EEPR, has been ordered to get the list but Vanin refuses to give in because then Mishenko would cut him loose. The IMF must get the list. Vanin hypnotized himself to forget the list's location and only his wife Olga can give the trigger command to let him remember. Jim gets Olga to the U.S. while Barney and the others clear out the EEPR Consulate with a bomb ruse and then take it over and stage a party where the reunited couple meet (while Mishenko waits across the street for Barney to defuse the bomb). The IMF fake partygoers sneak out and Mishenko shows up to find Vanin there. To prove his loyalty and that he didn't talk, Vanin has his wife give the trigger, unaware that the IMF are listening in and get to the bus where Vanin hid the list before Mishenko can.

Armand Anderssarian is an illegal arms dealer who is about to complete a multi-million dollar deal selling arms to guerrilla groups around the world - the IMF must stop him. Jim pretends to be setting up a theft of a secret radar system and Anderssarian ""sponsors"" Jim with $5 million through Minister Sartori then plans to sell the system for $20 million. Meanwhile Anderssarian loses his $5 million to Paris (with Barney providing an assist) in a poker game. The IMF team perform a fake raid (under the scrutiny of Anderssarian's aide Leon) on a IMF-staged radar station but the stuff is useless and Sartori wants to be reimbursed. When Anderssarian can't do so Sartori takes care of him for good.