Against the initial resistance of the Group, Frank travels to Portland, Oregon, to investigate a murder at an animal shelter. He meets with Jim Horn, a profiler and candidate for the Millennium Group. But Horn is distracted by his imminent divorce, and there is tension between him and Frank. When the killer strikes again, Horn is losing control, and Frank not only has to catch the killer who leaves grisly messages on his victims, but he has to contend with Horn as well who is more than ready to stop the murderer with terminal prejudice.

Maddie Haskel, twenty-years-old and heartland pretty, attends her mother's funeral in Joplan, Missouri. After the service, Maddie returns to her family's home, where she is approached by a vicious-looking man named Jim Gilroy. Gilroy's attempt to rape Maddie comes to a sudden halt when Maddie's boyfriend, Bobby Webber, emerges from the shadows wielding a length of iron pipe. After Gilroy is knocked unconscious, Bobby and Maddie drive off into the night with their prisoner safely tucked away in the trunk of their automobile. A Missouri State Trooper notices the vehicle has a burned-out tail light and orders Bobby to pull over. When the trooper hears noises emanating from the trunk, Bobby grabs a .357 and shoots and kills the trooper.

Frank enters a hospital emergency room looking for Catherine, who is working the night shift in child counseling. Suddenly, paramedics rush in with a bloodied woman on a gurney. Frank is inexplicably drawn to the stranger, and as he moves closer, notices a curved slash on her palm. He raises his own right hand, revealing a thin white scar which matches exactly the slash on the victim's hand. The woman dies from her injuries.

Attorney Al Pepper walks through a supermarket parking lot carrying a bag of groceries. A teenager, Sam, addresses Pepper and extends an open palm. Frank exits the supermarket and sees the two men. Suddenly, a bolt of light emanates from Sam's palm, knocking Pepper to the ground. Frank runs towards the scene, passing through panicking shoppers. When he arrives at Pepper's side, he discovers a handgun lying at Sam's feet.

Frank is asked by Catherine's father to investigate a case involving a friend whose son has been convicted of murder, and is soon convinced that the murder is linked to a serial killer called The Woodsman. Having claimed his latest victim, the Woodsman takes the body to a secluded campsite, covers the body in plastic, buries her under a pile of leaves and strikes up a conversation. Later, he is given photos by a mysterious stranger and asked to use them as 'targets' for future killings - one of which includes Catherine Black...

After Catherine Black goes missing in the Seattle Airport in the previous episode, Frank Black desperately searches for his wife, who has been abducted by a cunning stalker who is luring him into a trap.

Frank aids in the search for a man who is supposedly carrying a highly contagious virus and discovers the secret behind the Human Genome Project.

Millennium Group offender profiler Frank Black investigates the abduction of a bus full of schoolchildren, requiring the help of fellow Group members Peter Watts and Lara Means as he tracks a man preparing for a third world war.

Frank searches for a young man who disappeared in the Alaskan wilderness. In the Alaskan wilderness, the body of a young adult male, its face crushed beyond recognition, drifts down a river.

The discovery of the remains of the Crucifixion Cross threatens to divide the Millennium Group.

As the schism between the two warring Millennium Group factions deepens, Frank discovers the existence of yet another player in the power struggle.

Frank searches for a female serial killer and her lover after the pair escape from prison.

Frank senses that Bletcher's killer is responsible for the disappearance of a teenaged boy.

In this continuation of the previous episode... Jordan, Frank and Catherine bury the dead parakeet, prompting more questions from Jordan regarding God and the hereafter. Later, a Millennium team clad in bioharzard suits sweeps into the Davis home, where earlier an entire family was wiped out by the mysterious virus. Outside the house, in the backyard, are a dozen dead birds of various species.

The Marburg virus has apparently run its course. Several months after the death of his wife and a nervous breakdown, Frank rejoins the FBI and investigates a plane crash with a new partner.

Frank and Emma investigate a survivalist group worried about the Y2K bug.

Frank and Emma investigate murders on the set of a movie based on one of Frank's former cases.

The disappearance of a child leads a town to accuse a recently released sex offender who may or may not be guilty. Frank and Emma arrive to determine the truth.

Emma tries to help her drug addicted sister and learns that local addicts are exhibiting strange mutations linked to tainted heroin.

Peter's daughter is kidnapped by a Gulf War veteran who hopes to force the Millennium Group into admitting their crimes. Frank and Emma attempt to help, but Peter seems determined not to betray the secrets of the Group.

Lucy Butler returns to torment Frank. This times she is a nanny for a powerful Wisconsin politician.

A fundamentalist Jewish sect abducts a pregnant woman hoping to raise a pure child for the priesthood and force the coming of the Messiah.

Emma and Frank investigate the mysterious biological research conducted by a former Millennium Group member who is dying from a mysterious disease.

Frank and Emma investigate a murder in a small town where Emma spent part of her youth.

Frank is held responsible for a man's death while Emma joins with the Millennium Group.