Desperate Scousewives was a British reality television series based in Liverpool. It premiered on E4 at 10:00pm on 28 November 2011. It ran for eight episodes before it was officially announced that the show had been cancelled due to stagnating ratings and a perceived lack of interest in cast members from viewers. The show gained favourable viewing figures for its first episode debuting with 500,000 viewers, 24% up on the E4 channel's slot average. However, episodes for the rest of the series were regularly below this figure and outside of the E4 Top 10 weekly rankings.

The show's name is a play on words of the American comedy-drama Desperate Housewives and was said to be "Liverpool's answer to The Only Way Is Essex and Made in Chelsea". Repeats began airing on 4Music from 26 April 2012, sparking speculation from cast members that it may be a test run to recommission a new series on 4Music instead of E4. However, E4 reaffirmed their decision several times about the show's cancellation via their official Twitter page despite cast members continually claiming that a second series is in production.