The Heart, She Holler is a live action television series produced by PFFR for Adult Swim. The series, described as "Southern Gothic drama" and "an inside-out blend of soap opera and politically incorrect surrealist comedy," is about the long-lost son of the Heartshe dynasty – played by Patton Oswalt – returning to run the town and being locked in conflict with sisters Hurshe and Hambrosia. The show premiered on November 6, 2011, and its 14-episode second season premiered on September 11, 2013.

The title of the series is a play on words, in that the name of the family which controls the town is "Heartshe", and "Holler" is an Appalachian pronunciation of the word "hollow", meaning small valley, essentially making it "The Heartshe Hollow".