Dr. Tom Callaghan arrives in the remote town of Coopers Crossing to join the Royal Flying Doctor Service on missions to the homesteads, stock stations and mining camps of outback Australia.

Whilst trying to be accepted by the locals, a task made all the more difficult by the death of his first patient, Tom is unexpectedly introduced to Beth Drever and her daughter Liz, a New York advertising photographer, when Andy is forced to make an emergency landing.