When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist. After a copycat strikes, Will and Hannibal join forces to track down the culprit.

Will and Jack race to apprehend a serial killer using humans as fertilizer.

Abigail Hobbs comes out of her coma with new information about her father.

A series of family murders takes place.

Jack and Will search for a killer who turns his victims into angels.

The Chesapeake Ripper taunts Jack Crawford with guilt from the past.

Will races to stop a rogue surgeon extracting organs from his victims.

En musiker fra Baltimore Metropolitan Orchestra bliver fundet død, med en violinhals mast ned i munden, og Hannibals klient Franklyn er sikker på at det er hans ven Tobias der er morderen. Imponeret over mordets :|apostrofe|;elegance:|apostrofe|; inviterer Hannibal nu Tobias til middag.

Will, Jack and the BAU team hunt for a serial killer who creates a totem pole out of his victims' bodies.

When Dr. Gideon escapes to terrorize Alana and Dr. Chilton, Hannibal and Will go on the hunt. Eddie Izzard guest stars.

Hannibal convinces Jack and Alana that Will could be the copycat killer.

Hannibal frames Will, convincing Jack and Alana that Will's the copycat killer.