The Chesapeake Ripper taunts Jack Crawford with guilt from the past.

When Dr. Gideon escapes to terrorize Alana and Dr. Chilton, Hannibal and Will go on the hunt. Eddie Izzard guest stars.

With Will Graham in prison, the FBI investigates his claims against Hannibal. A new serial killer emerges.

As Will's murder trial begins, a copycat killer sends a gruesome message. Jack is under pressure to wrap up Will's case while Hannibal hopes for his friend's exoneration.

Emboldened after drug therapy from Dr. Chilton, Will sets a deadly plan in place to expose Hannibal. A new killer is turning victims into beehives.

The BSU investigates Beverly's death after her body is found displayed in a gruesome tableau. Abel Gideon returns to the Baltimore Hospital for the Criminally Insane. Will seeks a horrific revenge for Beverly's death.

Jack suspects Hannibal might be the Chesapeake Ripper as two more victims turn up. Hannibal and Alana distance themselves from Will.

As Miriam Lass begins her recovery, Will is released from prison and resumes his pursuit of Hannibal.

After surviving a disfiguring gunshot, Dr. Fredrick Chilton is now focused on rallying support to capture Hannibal, using Will as bait. Jack is distracted by Bella's failing health, but he implores Will to abandon the risky idea of finding Hannibal. Meanwhile, Alana Bloom entertains a different approach, potentially partnering with Mason Verger to utilize his vast resources.

Dr. Hannibal Lecter has been under lock and key for three years at the Baltimore State Hospital for the Criminally Insane, when a new villain arises in Francis Dolarhyde, also known as "The Tooth Fairy." As the investigation unfolds Jack Crawford approaches Will Graham to help catch this vicious serial killer who is targeting families.

Will Graham and the FBI enlist the expertise of Dr. Fredrick Chilton in the hopes of luring Francis Dolarhyde into an ambush, using Freddie Lounds as their mouthpiece. As Will's empathy for Dolarhyde begins to affect his fragile psyche, Bedelia Du Maurier warns that the killer Will should be most concerned about at the moment is himself. Meanwhile, Dolarhyde senses that the FBI is closing in and launches a horrifying endgame.

In a desperate bid to slay Francis Dolarhyde, Will Graham engineers a cunning ploy utilizing Hannibal Lecter. Upon learning of his plan, Bedelia Du Maurier voices concerns that Will's actions may not only put his life in peril, but the lives of those around him. As the end draws near, Will remains unflinching in his game with Hannibal-even when it means coming face-to-face with his own darkest fears?