Neuroscience professor Daniel Pierce (Eric McCormack) is recruited by a former student, FBI Agent Kate Moretti (Rachael Leigh Cook), to help out on a case involving the death of a pharmaceutical executive. But Daniel's schizophrenic hallucinations could potentially derail the investigation.

Pierce is enlisted to help crack the case of a murdered mail-order bride. A twist marks the investigation when it's discovered the prime suspect suffers from an unusual condition. Elsewhere, Moretti is drawn to a handsome new professor.

Pierce and Moretti race to find clues when a serial killer from 1986 begins killing again. They catch a break when they learn that one of the victims is actually alive. Moretti's dad, one of the investigators on the original case, offers his daughter advice. Pamela Reed also guest-stars as the mother of the surviving victim, while Armin Shimerman is the victim's psychologist.

When a young man in a cult claims to be hearing the word of God, Pierce must determine if it’s actually the word of God or a life-threatening neurological condition. Pierce and Moretti must also figure out if his murder is linked to his drug past or his new life with an organization that may be scamming people out of their life savings. Roger Bart guest-stars as Ethan Kendrick, a high-powered IRS agent looking into the finances of the organization. Meanwhile, the university gives Pierce an award for his research.

Pierce is called upon to help the FBI investigate the murder of a therapist. Moretti spends more time with Professor Hathaway. And Dean Haley uses Pierce as bait to get a wealthy alumni’s widow to fund a new building.

Pierce must take a deep look into his own life when he is brought into a case involving a schizophrenic. Meanwhile, Moretti stops at nothing to impress her new boss at the FBI. Guest star Tom Sizemore plays a top-level Irish mobster, while guest star Edward Furlong plays a would-be tough guy who may have played a crucial role in the crime.

Moretti and Pierce are called upon to solve a crime in their own backyard when a college student is killed in her dorm room. Pierce is forced into the uncomfortable situation of interacting on a personal level with more than one of his students, which forces him to confront difficult truths about his own past. The case comes just as Moretti is beginning to re-evaluate her relationship with Dr. Hathaway.

A student tips off Pierce about a potential conspiracy to cover up the murder of a U.S. Senator.

Moretti learns that there may be some truth to Pierce's conspiracy theory; Pierce's new doctor forces him to face the truth about Natalie.