Ryan forms a unique connection with his neighbor's dog after a failed suicide attempt.

Wilfred is angry after Ryan tricks him into going to the veterinarian.

Ryan gets his wallet back (that's the good news) when his malevolent, porn-addicted neighbor Spencer shows up. The bad news? Spencer's looking for answers about who broke into his house. He's also looking for blood.

Ryan tries to reconcile with his sister, and Wilfred is in for a shock at doggy day care as a result.

Wilfred reveals an extraordinary ability when Ryan takes him to a hospice to volunteer.

Wilfred persuades Ryan to help him get rid of Jenna’s boyfriend.

Ryan must swallow his pride when Wilfred pursues a new love interest., and Ryan meets a new romantic interest himself

Ryan has a guilt complex over the death of his childhood dog, and Wilfred, upon learning of it, goes to otherworldly lengths to help Ryan discover the truth about how the pooch passed on. Meanwhile, Kristen throws a party for her boss.

Wilfred tries to find Ryan a human friend.

Ryan meets someone who questions Ryan's friendship to Wilfred.

Just as Ryan finds happiness in his life, Wilfred begs him to sacrifice it for a larger purpose.

A crisis arises when Ryan ignores Wilfred's advice.