Dr. Emmet Cole, adventurer and TV personality goes missing deep in the Amazon. After a string search for him, his family and friends hold a memorial service in his honor. His wife, Tess, tries to face the reality of her husband death, while her son, Lincoln, is more than ready to move on. Six months later Emmet's location beacon catches a mysterious signal. Tess and Lincoln join her and Emmet's film crew on a journey through the Amazon to find him.

The spirit of Dr. Emmet gets into Jahel, the message is clear, go home! Tess then is determined to go and find clues to Cole's whereabouts. While on the mission, they discover a tree with children dolls that is suspected to guard of the "spirit of the abandoned girl" who drowned in the river. Then, a member of the crew goes missing and they realize they have to survive the nightmare of an angry spirit.

When the crew of the Magus goes blind from tree spores, lone holdout AJ must overcome his most-paralyzing fear to find a cure before the blindness becomes permanent; the local tribe stalks the crew and judges if they are worthy to stay in the jungle.

The Magus team encounters one of Emmet's colleagues who disappeared six months ago and discover he's been the victim of a mystical curse that is a life or death matter. But when the others plan to leave and continue the mission, Lincoln must face this challenge and be the moral compass.

The Magus crew are run aground by another vessel, and soon learn that the seemingly welcoming crew members of a ship claiming to have come to their rescue have in fact a very different agenda, causing a dire, life-and-death situation. The crew also make a shocking discovery that will leave one of them in tears.

The Magus crew find themselves in a stark predicament as they're stalked by a cannibalistic terror while searching through an abandoned research facility following mysterious clues that suggest Dr. Emmet Cole may still be alive. Meanwhile, security force leader Kurt is forced to make a heavy personal sacrifice when it comes to the safety of the crew.

With a course now plotted for their final destination, the Magus crew suddenly finds itself in complete chaos when a member of their own is shot dead, leading Jahel to call upon the spirit of the Boiúna to help, against the wishes of her father. The crew's quest is threatened further by the unknown killer, as the situation continues to spiral out of control.