A new yorki Dr. Zoe Hart nagyon elkeseredik, amikor kiderül, hogy az áhított mellkas-sebészi ösztöndíjához azt a feltételt szabják, hogy egy évig háziorvosként kell dolgoznia. Végül az alabamai Bluebell-ben köt ki, ahol azonban nagy meglepetés éri: dr. Harley Wilkes, aki mellett praktizált volna, elhunyt, és a fele praxisát rá hagyta, azonban a praxison a kissé öntelt dr. Brick Breeland-del kell osztoznia...

Zoe lassan kezd megbarátkozni a kisvárossal, bár sokaknak feltűnik túlságosan rövid sortja és a polgármesterhez fűződő jó kapcsolata. Annak ellenére, hogy nemrég megmentette a vajúdó Mabel és gyermeke életét, Brick nem hajlandó elismerni kollégája létjogosultságát a városban. Mikor egy kisebb sérülés miatt Zoe megvizsgálja Brick unokahúgát, Betty-t, rájön, hogy a lány titkolja, hogy szklerózis multiplexe van. Zoe emiatt nem engedi fellépni Betty-t a város évenkénti parádéján, amelynek azonban Lemon az egyik fő szervezője.

Zoe eltökélte, hogy megmutatja a városiaknak, hogy igenis Bluebell-ben van a helye - mi több, szeretné megnyerni az éves főzőversenyt is, ahol az utóbbi időben mindig Brick győzedelmeskedett. Mikor Lemon értesül róla, hogy Lavon-nak tetszik apja rendelőjének új recepciósa, Didi, a lány bizalmába férkőzik, majd intéz neki egy jobban fizető állást egy másik városban.

Mivel Brick egy hétre elutazott, Zoe abban bízik, hogy ha elnyeri a bluebell-iek bizalmát, a férfi visszatérése után is hozzá fognak menni a betegek. A város tiszteletese kínos ügybe keveredik: Zoe szerint pozitív lett a szifilisz-tesztje. Lemon nagy reményeket fűz ahhoz, hogy ő lesz a Múltőrző Matrónák szervezet új elnöke, de félő, hogy George akaratlanul is keresztülhúzta a számításait.

Brick egy focimeccsre készülődik és - mint ahogy az megszokott - kisebbik lányát, Magnoliát Lemon-ra bízza. Azonban Magnolia egy buliban alkoholmérgezést kap - csak Rose-nak és Zoe-nak köszönhető, hogy nem történik nagyobb baja. Zoe úgy érzi, nem tudja megbocsátani anyja hazugságát és mereven elzárkózik a kapcsolatfelvétel elől. Az erdőben majdnem elüt egy férfit, akiről kiderül, hogy több mint egy éve halott.

Zoe döbbenten értesül róla, hogy Wade nős. Mi több, a feleség, Tansy a városba érkezik, hogy felbontsák a házasságot, azonban mikor Wade megtudja, hogy a lány kihez akar hozzámenni, széttépi a válási papírokat. Lemon és Lavon egy jótékonysági teknős-verseny műsorvezetői feladatát látják el és elhatározzák, hogy megpróbálnak baráti kapcsolatot kialakítani.

A városban Öregdiák Hét van és Lavon felajánlja Zoe-nak, hogy tartsa ő az öregdiák meccs előtti hagyományos vacsorát, így részt vehet az ünnepségsorozatban. Azonban amikor megérkezik Zoe new yorki barátnője, Gigi, és kezébe veszi a parti megszervezését, nem várt bonyodalmak bukkannak fel. Lemon, Wade és George egy régi, gimnáziumi ellenségnek akarnak visszavágni egy diákcsínnyel, ami nem a tervek szerint sül el.

While the residents of Bluebell prepare for their annual Planksgiving celebration, Zoe anxiously counts the days until her return home to New York for Thanksgiving. Unfortunately, getting out of town may be a bit trickier than Zoe anticipated due to the fact that she has to meet her thirty percent quota of patients by midnight or lose her share of the practice to Brick. Meanwhile, Lavon encourages Wade to be honest about his feelings for Zoe, and George’s father offers him an opportunity to join his law firm in Montgomery, which isn’t exactly music to Lemon’s ears.

Zoe encourages Rose to enter the annual Miss Cinnamon Cider Pageant even though Lemon’s younger sister, Magnolia Breeland, is a shoo-in to win. Of course, with Zoe coaching Rose and Lemon coaching Magnolia, rivalry takes on a whole new meaning. Meanwhile, George and Wade go on a road trip to pick up a Christmas tree for Bluebell’s town square. Also, in flashbacks, we learn some of the history of Lemon’s relationship with her mother, as well as the details of when Lemon and Lavon first realized they had a connection.

When Zoe goes in search of some family history in Bluebell, she discovers that she is a legacy to the Bluebell Belles. Of course, once Lemon catches wind of the news, she makes it her sole mission in life to make sure Zoe doesn’t become an official Belle and puts her through a humiliating initiation. With the help of Wade, Lavon attempts to jump back into the dating scene, but he finds it difficult because Didi is telling everyone that he’s in love with her. Meanwhile, George devises a plan to stop a huge chainstore from building near Bluebell and as a result driving business away from the town.

Zoe is so uncharacteristically happy as of late that it causes her friends to speculate as to the possible reason behind her new attitude. Turns out that Zoe is hiding her new friendship with AnnaBeth, who doesn't want Lemon to find out since Zoe is Lemon's sworn enemy. Lemon campaigns to become the Belles' new Memory Matron, but she has to overcome a few obstacles to secure the honored position.

Zoe decides that it’s too soon in her relationship with Judson to go to the annual Sweetie Pie Dance so instead she makes plans to have a sleepover with Rose, whose parents are going out of town. George misplaces the save the dates for his upcoming wedding which causes major trouble in Lemon paradise. Lemon wants her father to finally move on from her mother leaving him, so she secretly gets him a date for the dance.

Wade somehow convinces Lemon to dress up as Joelle as part of a scheme to convince Joelle’s ex-boyfriend that he didn’t actually see Wade and Joelle together. Lavon asks Zoe to help him figure out why Didi has been avoiding him, but once Zoe uncovers the shocking reason she isn’t quite sure what to do with the information. George comes to Zoe for advice in determining whether there is a medical explanation for the behavior of one of his clients.

Zoe Hart is thrilled to see snow in Bluebell, but the rest of the town is superstitious that it will bring bad luck. When Lavon’s parents make a visit to Bluebell, Lavon thinks it’s the perfect opportunity to introduce them to Didi, but the introduction doesn’t exactly go according to plan. Lemon and George make a big decision about their future.

Much to Brick’s disappointment, George is named Bluebell’s Man of the Year. As the town’s mayor, Lavon is expected to host a cocktail party in George’s honor, but for obvious reasons this is a difficult situation for Lavon given his history with Lemon. Fortunately for Lavon, Zoe agrees to step in and help him with the party, but things take a turn for the disastrous when Zoe has to improvise a speech at the gathering. Meanwhile, Magnolia begs Wade to write a song and perform it with her at the party.

Zoe has conflicted feelings about seeing her estranged father, world-renowned surgeon Ethan Hart, who has agreed to travel to Bluebell to perform surgery on George’s father as a favor to Zoe. Fearful of losing George, Lemon decides she must befriend Zoe in order to prevent her from telling George about Lemon’s affair with Lavon. Meanwhile, to celebrate the 30th anniversary of the Rammer Jammer, the owner hosts a signature cocktail contest between Wade and Shelley.

Zoe makes a romantic connection with one of her patients, Jesse, and accepts his invitation to lunch. Lemon agrees to let Magnolia plan her bachelorette party as long as she follows Lemon’s strict instructions, but Magnolia has some more “interesting” plans in store for her big sister. Wade plans a hunting trip for George’s bachelor party.

After a wild night of partying, Wade wakes up with a massive hangover, an uninvited houseguest and no memory of what happened the night before. Meanwhile, George takes an unplanned roadtrip to New Orleans, and Lemon finally confesses her troubles to her father, Brick.

Wade signs up for the Bluebell Battle in hopes of winning the five thousand dollar prize, but when he strikes out finding someone to be his race partner, he must swallow his pride and ask Zoe. Meanwhile, Rose is jumping for joy when Frederick Dean finally asks her out on a date, and George and Lemon meet with Reverend Mayfair to discuss their relationship issues.

Zoe blames herself when one of her friends faces a health crisis and she didn’t notice the symptoms. With much encouragement from Lavon, Wade explores the idea of opening his own bar in Bluebell. Meanwhile, Lemon plans a romantic night for George, hoping to get their relationship back on track. Gary Cole returns as Zoe’s father, Ethan Hart.

With an impending storm about to hit Bluebell, George and Lemon prepare for their wedding day. Meanwhile, taking shelter from the storm, Zoe finds herself stranded in a barn with Wade.