After being diagnosed with a degenerative neurological disorder, Chicago Mayor Tom Kane must set aside his personal issues as he attempts to run the city with an iron fist, while also dealing with the upcoming gubernatorial primary.

With a new, powerful entry in the race, Kane and his people flex their political muscles to maintain their hold. Meanwhile, a worried Meredith suspects her husband is keeping something from her.

With Zajac's campaign gathering steam, Kane needs to adjust to his health situation; Miller digs deep to come up with some embarrassing dirt on Gov. Cullen.

Kane finds himself starting to lose control, both politically and personally, as his supporters begin to question their confidence in him. Zajac ventures into uncharted territory while campaigning as Miller continues to dig for answers.

After long-buried information resurfaces, Kane and his camp find themselves battling the media for control of public perception. With the primary just around the corner, they'll have to pull out all the stops to contain the situation and keep the upper hand.

Kane takes an unannounced break from City Hall as his political image hits an all-time low. The election looms and he'll need to enlist the help of others to weather this storm. Kitty, at an emotional impasse, makes a bold move while Meredith, increasingly suspect of Kane's behavior, seeks opportunities of her own.

Election Day. The race is close, and while the candidates campaign, Kane and Stone must do their part to turn the gears of the political machine. Emma's world is turned upside-down while Meredith must go to great lengths to prove her allegiance to Kane.